Le A - Search Results

1

Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia-cell cycle dual reporter.

Le A, Stine ZE, Nguyen C, Afzal J, Sun P, Hamaker M, Siegel NM, Gouw AM, Kang BH, Yu SH, Cochran RL, Sailor KA, Song H, Dang CV. Le A, et al. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12486-91. doi: 10.1073/pnas.1402012111. Epub 2014 Aug 11. Proc Natl Acad Sci U S A. 2014. PMID: 25114222 Free PMC article.

2

MYC-induced cancer cell energy metabolism and therapeutic opportunities.

Dang CV, Le A, Gao P. Dang CV, et al. Among authors: le a. Clin Cancer Res. 2009 Nov 1;15(21):6479-83. doi: 10.1158/1078-0432.CCR-09-0889. Epub 2009 Oct 27. Clin Cancer Res. 2009. PMID: 19861459 Free PMC article. Review.

3

Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model.

Yustein JT, Liu YC, Gao P, Jie C, Le A, Vuica-Ross M, Chng WJ, Eberhart CG, Bergsagel PL, Dang CV. Yustein JT, et al. Among authors: le a. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3534-9. doi: 10.1073/pnas.0901230107. Epub 2010 Feb 2. Proc Natl Acad Sci U S A. 2010. PMID: 20133585 Free PMC article.

4

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression.

Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV. Le A, et al. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42. doi: 10.1073/pnas.0914433107. Epub 2010 Jan 19. Proc Natl Acad Sci U S A. 2010. PMID: 20133848 Free PMC article.

5

Therapeutic targeting of cancer cell metabolism.

Dang CV, Hamaker M, Sun P, Le A, Gao P. Dang CV, et al. Among authors: le a. J Mol Med (Berl). 2011 Mar;89(3):205-12. doi: 10.1007/s00109-011-0730-x. Epub 2011 Feb 8. J Mol Med (Berl). 2011. PMID: 21301795 Free PMC article. Review.

6

Metabolic and electrochemical mechanisms of dimeric naphthoquinones cytotoxicity in breast cancer cells.

Emadi A, Le A, Harwood CJ, Stagliano KW, Kamangar F, Ross AE, Cooper CR, Dang CV, Karp JE, Vuica-Ross M. Emadi A, et al. Among authors: le a. Bioorg Med Chem. 2011 Dec 1;19(23):7057-62. doi: 10.1016/j.bmc.2011.10.005. Epub 2011 Oct 8. Bioorg Med Chem. 2011. PMID: 22036210 Free PMC article.

7

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.

Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, Tsukamoto T, Rojas CJ, Slusher BS, Zhang H, Zimmerman LJ, Liebler DC, Slebos RJ, Lorkiewicz PK, Higashi RM, Fan TW, Dang CV. Le A, et al. Cell Metab. 2012 Jan 4;15(1):110-21. doi: 10.1016/j.cmet.2011.12.009. Cell Metab. 2012. PMID: 22225880 Free PMC article.

8

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.

Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW, Phang JM. Liu W, et al. Among authors: le a. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8983-8. doi: 10.1073/pnas.1203244109. Epub 2012 May 21. Proc Natl Acad Sci U S A. 2012. PMID: 22615405 Free PMC article.

9

Conceptual framework for cutting the pancreatic cancer fuel supply.

Le A, Rajeshkumar NV, Maitra A, Dang CV. Le A, et al. Clin Cancer Res. 2012 Aug 15;18(16):4285-90. doi: 10.1158/1078-0432.CCR-12-0041. Clin Cancer Res. 2012. PMID: 22896695 Free PMC article. Review.

10

Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors.

Dutta P, Le A, Vander Jagt DL, Tsukamoto T, Martinez GV, Dang CV, Gillies RJ. Dutta P, et al. Among authors: le a. Cancer Res. 2013 Jul 15;73(14):4190-5. doi: 10.1158/0008-5472.CAN-13-0465. Epub 2013 May 30. Cancer Res. 2013. PMID: 23722553 Free PMC article.

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