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CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner.
Huising MO, van der Meulen T, Vaughan JM, Matsumoto M, Donaldson CJ, Park H, Billestrup N, Vale WW. Huising MO, et al. Among authors: van der meulen t. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):912-7. doi: 10.1073/pnas.0913610107. Epub 2009 Dec 22. Proc Natl Acad Sci U S A. 2010. PMID: 20080775 Free PMC article.
CRFR1 activation protects against cytokine-induced β-cell death.
Blaabjerg L, Christensen GL, Matsumoto M, van der Meulen T, Huising MO, Billestrup N, Vale WW. Blaabjerg L, et al. Among authors: van der meulen t. J Mol Endocrinol. 2014 Dec;53(3):417-27. doi: 10.1530/JME-14-0056. Epub 2014 Oct 16. J Mol Endocrinol. 2014. PMID: 25324488 Free PMC article.
Data-driven synthesis of proteolysis-resistant peptide hormones.
Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Prothiwa M, et al. Among authors: van der meulen t. J Am Chem Soc. 2014 Dec 24;136(51):17710-3. doi: 10.1021/ja5065735. Epub 2014 Dec 12. J Am Chem Soc. 2014. PMID: 25496053
45 results