Smith BJ - Search Results

1

Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax.

Sleebs BE, Gazdik M, O'Neill MT, Rajasekaran P, Lopaticki S, Lackovic K, Lowes K, Smith BJ, Cowman AF, Boddey JA. Sleebs BE, et al. Among authors: smith bj. J Med Chem. 2014 Sep 25;57(18):7644-62. doi: 10.1021/jm500797g. Epub 2014 Sep 11. J Med Chem. 2014. PMID: 25167370

2

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.

Sleebs BE, Czabotar PE, Fairbrother WJ, Fairlie WD, Flygare JA, Huang DC, Kersten WJ, Koehler MF, Lessene G, Lowes K, Parisot JP, Smith BJ, Smith ML, Souers AJ, Street IP, Yang H, Baell JB. Sleebs BE, et al. Among authors: smith ml, smith bj. J Med Chem. 2011 Mar 24;54(6):1914-26. doi: 10.1021/jm101596e. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366295

3

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

Sleebs BE, Lopaticki S, Marapana DS, O'Neill MT, Rajasekaran P, Gazdik M, Günther S, Whitehead LW, Lowes KN, Barfod L, Hviid L, Shaw PJ, Hodder AN, Smith BJ, Cowman AF, Boddey JA. Sleebs BE, et al. Among authors: smith bj. PLoS Biol. 2014 Jul 1;12(7):e1001897. doi: 10.1371/journal.pbio.1001897. eCollection 2014 Jul. PLoS Biol. 2014. PMID: 24983235 Free PMC article.

4

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.

Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, Lopaticki S, Nebl T, Triglia T, Smith BJ, Lowes K, Boddey JA, Cowman AF. Hodder AN, et al. Among authors: smith bj. Nat Struct Mol Biol. 2015 Aug;22(8):590-6. doi: 10.1038/nsmb.3061. Epub 2015 Jul 27. Nat Struct Mol Biol. 2015. PMID: 26214367

5

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum.

Hodder AN, Maier AG, Rug M, Brown M, Hommel M, Pantic I, Puig-de-Morales-Marinkovic M, Smith B, Triglia T, Beeson J, Cowman AF. Hodder AN, et al. Mol Microbiol. 2009 Jan;71(1):48-65. doi: 10.1111/j.1365-2958.2008.06508.x. Epub 2008 Nov 5. Mol Microbiol. 2009. PMID: 19007413 Free PMC article.

6

Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum.

Maier AG, Baum J, Smith B, Conway DJ, Cowman AF. Maier AG, et al. Infect Immun. 2009 Apr;77(4):1689-99. doi: 10.1128/IAI.01331-08. Epub 2009 Feb 9. Infect Immun. 2009. PMID: 19204093 Free PMC article.

7

Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.

Lee EF, Czabotar PE, Yang H, Sleebs BE, Lessene G, Colman PM, Smith BJ, Fairlie WD. Lee EF, et al. Among authors: smith bj. J Biol Chem. 2009 Oct 30;284(44):30508-17. doi: 10.1074/jbc.M109.040725. Epub 2009 Sep 2. J Biol Chem. 2009. PMID: 19726685 Free PMC article.

8

Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum.

Hodder AN, Czabotar PE, Uboldi AD, Clarke OB, Lin CS, Healer J, Smith BJ, Cowman AF. Hodder AN, et al. Among authors: smith bj. J Biol Chem. 2012 Sep 21;287(39):32922-39. doi: 10.1074/jbc.M112.350504. Epub 2012 Jul 26. J Biol Chem. 2012. PMID: 22843685 Free PMC article.

9

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes.

Chen L, Xu Y, Healer J, Thompson JK, Smith BJ, Lawrence MC, Cowman AF. Chen L, et al. Among authors: smith bj. Elife. 2014 Oct 8;3:e04187. doi: 10.7554/eLife.04187. Elife. 2014. PMID: 25296023 Free PMC article.

10

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell.

Coffey MJ, Sleebs BE, Uboldi AD, Garnham A, Franco M, Marino ND, Panas MW, Ferguson DJ, Enciso M, O'Neill MT, Lopaticki S, Stewart RJ, Dewson G, Smyth GK, Smith BJ, Masters SL, Boothroyd JC, Boddey JA, Tonkin CJ. Coffey MJ, et al. Among authors: smith bj. Elife. 2015 Nov 18;4:e10809. doi: 10.7554/eLife.10809. Elife. 2015. PMID: 26576949 Free PMC article.

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