Griffin PR - Search Results

1

HDX-MS guided drug discovery: small molecules and biopharmaceuticals.

Marciano DP, Dharmarajan V, Griffin PR. Marciano DP, et al. Among authors: griffin pr. Curr Opin Struct Biol. 2014 Oct;28:105-11. doi: 10.1016/j.sbi.2014.08.007. Epub 2014 Aug 30. Curr Opin Struct Biol. 2014. PMID: 25179005 Free PMC article. Review.

2

The Deuterator: software for the determination of backbone amide deuterium levels from H/D exchange MS data.

Pascal BD, Chalmers MJ, Busby SA, Mader CC, Southern MR, Tsinoremas NF, Griffin PR. Pascal BD, et al. Among authors: griffin pr. BMC Bioinformatics. 2007 May 16;8:156. doi: 10.1186/1471-2105-8-156. BMC Bioinformatics. 2007. PMID: 17506883 Free PMC article.

3

A two-stage differential hydrogen deuterium exchange method for the rapid characterization of protein/ligand interactions.

Chalmers MJ, Busby SA, Pascal BD, Southern MR, Griffin PR. Chalmers MJ, et al. Among authors: griffin pr. J Biomol Tech. 2007 Sep;18(4):194-204. J Biomol Tech. 2007. PMID: 17916792 Free PMC article.

4

Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange.

Zhang X, Chien EY, Chalmers MJ, Pascal BD, Gatchalian J, Stevens RC, Griffin PR. Zhang X, et al. Among authors: griffin pr. Anal Chem. 2010 Feb 1;82(3):1100-8. doi: 10.1021/ac902484p. Anal Chem. 2010. PMID: 20058880 Free PMC article.

5

Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics.

Solt LA, Griffin PR, Burris TP. Solt LA, et al. Among authors: griffin pr. Curr Opin Lipidol. 2010 Jun;21(3):204-11. doi: 10.1097/MOL.0b013e328338ca18. Curr Opin Lipidol. 2010. PMID: 20463469 Free PMC article. Review.

6

Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer.

Zhang J, Chalmers MJ, Stayrook KR, Burris LL, Garcia-Ordonez RD, Pascal BD, Burris TP, Dodge JA, Griffin PR. Zhang J, et al. Among authors: griffin pr. Structure. 2010 Oct 13;18(10):1332-41. doi: 10.1016/j.str.2010.07.007. Structure. 2010. PMID: 20947021 Free PMC article.

7

Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions.

Chalmers MJ, Busby SA, Pascal BD, West GM, Griffin PR. Chalmers MJ, et al. Among authors: griffin pr. Expert Rev Proteomics. 2011 Feb;8(1):43-59. doi: 10.1586/epr.10.109. Expert Rev Proteomics. 2011. PMID: 21329427 Free PMC article. Review.

8

Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.

West GM, Chien EY, Katritch V, Gatchalian J, Chalmers MJ, Stevens RC, Griffin PR. West GM, et al. Among authors: griffin pr. Structure. 2011 Oct 12;19(10):1424-32. doi: 10.1016/j.str.2011.08.001. Epub 2011 Sep 1. Structure. 2011. PMID: 21889352 Free PMC article.

9

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.

Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, Vidović D, Shulman GI, Spiegelman BM, Griffin PR. Choi JH, et al. Among authors: griffin pr. Nature. 2011 Sep 4;477(7365):477-81. doi: 10.1038/nature10383. Nature. 2011. PMID: 21892191 Free PMC article.

10

Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution.

Landgraf RR, Chalmers MJ, Griffin PR. Landgraf RR, et al. Among authors: griffin pr. J Am Soc Mass Spectrom. 2012 Feb;23(2):301-9. doi: 10.1007/s13361-011-0298-2. Epub 2011 Dec 1. J Am Soc Mass Spectrom. 2012. PMID: 22131230 Free PMC article.

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