Le KN - Search Results

1

Complement inhibition in cynomolgus monkeys by anti-factor d antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration.

Loyet KM, Good J, Davancaze T, Sturgeon L, Wang X, Yang J, Le KN, Wong M, Hass PE, van Lookeren Campagne M, Haughney PC, Morimoto A, Damico-Beyer LA, DeForge LE. Loyet KM, et al. Among authors: le kn. J Pharmacol Exp Ther. 2014 Dec;351(3):527-37. doi: 10.1124/jpet.114.215921. Epub 2014 Sep 17. J Pharmacol Exp Ther. 2014. PMID: 25232192

2

A mechanistic pharmacokinetic/pharmacodynamic model of factor D inhibition in cynomolgus monkeys by lampalizumab for the treatment of geographic atrophy.

Le KN, Gibiansky L, Good J, Davancaze T, van Lookeren Campagne M, Loyet KM, Morimoto A, Jin J, Damico-Beyer LA, Hanley WD. Le KN, et al. J Pharmacol Exp Ther. 2015 Nov;355(2):288-96. doi: 10.1124/jpet.115.227223. J Pharmacol Exp Ther. 2015. PMID: 26359312

3

Population Pharmacokinetics and Pharmacodynamics of Lampalizumab Administered Intravitreally to Patients With Geographic Atrophy.

Le KN, Gibiansky L, van Lookeren Campagne M, Good J, Davancaze T, Loyet KM, Morimoto A, Strauss EC, Jin JY. Le KN, et al. CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):595-604. doi: 10.1002/psp4.12031. Epub 2015 Oct 8. CPT Pharmacometrics Syst Pharmacol. 2015. PMID: 26535160 Free PMC article.

4

Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration.

Yaspan BL, Williams DF, Holz FG, Regillo CD, Li Z, Dressen A, van Lookeren Campagne M, Le KN, Graham RR, Beres T, Bhangale TR, Honigberg LA, Smith A, Henry EC, Ho C, Strauss EC; MAHALO Study Investigators. Yaspan BL, et al. Among authors: le kn. Sci Transl Med. 2017 Jun 21;9(395):eaaf1443. doi: 10.1126/scitranslmed.aaf1443. Sci Transl Med. 2017. PMID: 28637922 Clinical Trial.

5

Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD.

Avery RL, Castellarin AA, Steinle NC, Dhoot DS, Pieramici DJ, See R, Couvillion S, Nasir MA, Rabena MD, Le K, Maia M, Visich JE. Avery RL, et al. Br J Ophthalmol. 2014 Dec;98(12):1636-41. doi: 10.1136/bjophthalmol-2014-305252. Epub 2014 Jul 7. Br J Ophthalmol. 2014. PMID: 25001321 Free PMC article.

6

SYSTEMIC PHARMACOKINETICS AND PHARMACODYNAMICS OF INTRAVITREAL AFLIBERCEPT, BEVACIZUMAB, AND RANIBIZUMAB.

Avery RL, Castellarin AA, Steinle NC, Dhoot DS, Pieramici DJ, See R, Couvillion S, Nasir MA, Rabena MD, Maia M, Van Everen S, Le K, Hanley WD. Avery RL, et al. Retina. 2017 Oct;37(10):1847-1858. doi: 10.1097/IAE.0000000000001493. Retina. 2017. PMID: 28106709 Free PMC article. Clinical Trial.

7

Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.

Nijsen MJMA, Wu F, Bansal L, Bradshaw-Pierce E, Chan JR, Liederer BM, Mettetal JT, Schroeder P, Schuck E, Tsai A, Xu C, Chimalakonda A, Le K, Penney M, Topp B, Yamada A, Spilker ME. Nijsen MJMA, et al. CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):135-146. doi: 10.1002/psp4.12282. Epub 2018 Feb 1. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29349875 Free PMC article. Review.

8

Applications of Quantitative Systems Pharmacology in Model-Informed Drug Discovery: Perspective on Impact and Opportunities.

Bradshaw EL, Spilker ME, Zang R, Bansal L, He H, Jones RDO, Le K, Penney M, Schuck E, Topp B, Tsai A, Xu C, Nijsen MJMA, Chan JR. Bradshaw EL, et al. CPT Pharmacometrics Syst Pharmacol. 2019 Nov;8(11):777-791. doi: 10.1002/psp4.12463. Epub 2019 Oct 25. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31535440 Free PMC article.

9

Population pharmacokinetic and exposure-response analyses of ivosidenib in patients with IDH1-mutant advanced hematologic malignancies.

Jiang X, Wada R, Poland B, Kleijn HJ, Fan B, Liu G, Liu H, Kapsalis S, Yang H, Le K. Jiang X, et al. Clin Transl Sci. 2021 May;14(3):942-953. doi: 10.1111/cts.12959. Epub 2021 Jan 25. Clin Transl Sci. 2021. PMID: 33493392 Free PMC article. Clinical Trial.

10

Physiologically based pharmacokinetic modeling and simulation to predict drug-drug interactions of ivosidenib with CYP3A perpetrators in patients with acute myeloid leukemia.

Prakash C, Fan B, Ke A, Le K, Yang H. Prakash C, et al. Cancer Chemother Pharmacol. 2020 Nov;86(5):619-632. doi: 10.1007/s00280-020-04148-3. Epub 2020 Sep 25. Cancer Chemother Pharmacol. 2020. PMID: 32978634

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