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A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1.
Johnson J, Freedman H, Logan M, Wong JAJ, Hockman D, Chen C, He J, Beard MR, Eyre NS, Baumert TF, Tyrrell DL, Law JLM, Houghton M. Johnson J, et al. Among authors: tyrrell dl. J Virol. 2019 Oct 29;93(22):e00810-19. doi: 10.1128/JVI.00810-19. Print 2019 Nov 15. J Virol. 2019. PMID: 31462563 Free PMC article.
A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans.
Law JL, Chen C, Wong J, Hockman D, Santer DM, Frey SE, Belshe RB, Wakita T, Bukh J, Jones CT, Rice CM, Abrignani S, Tyrrell DL, Houghton M. Law JL, et al. Among authors: tyrrell dl. PLoS One. 2013;8(3):e59776. doi: 10.1371/journal.pone.0059776. Epub 2013 Mar 19. PLoS One. 2013. PMID: 23527266 Free PMC article.
An inactivated hepatitis C virus vaccine on the horizon?
Houghton M, Law JL, Tyrrell DL. Houghton M, et al. Among authors: tyrrell dl. Gastroenterology. 2013 Aug;145(2):285-8. doi: 10.1053/j.gastro.2013.06.029. Epub 2013 Jun 25. Gastroenterology. 2013. PMID: 23806539 No abstract available.
Effect of Different Adjuvants on the Longevity and Strength of Humoral and Cellular Immune Responses to the HCV Envelope Glycoproteins.
Akache B, Deschatelets L, Harrison BA, Dudani R, Stark FC, Jia Y, Landi A, Law JLM, Logan M, Hockman D, Kundu J, Tyrrell DL, Krishnan L, Houghton M, McCluskie MJ. Akache B, et al. Among authors: tyrrell dl. Vaccines (Basel). 2019 Dec 3;7(4):204. doi: 10.3390/vaccines7040204. Vaccines (Basel). 2019. PMID: 31816920 Free PMC article.
SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1.
Law JLM, Logan M, Joyce MA, Landi A, Hockman D, Crawford K, Johnson J, LaChance G, Saffran HA, Shields J, Hobart E, Brassard R, Arutyunova E, Pabbaraju K, Croxen M, Tipples G, Lemieux MJ, Tyrrell DL, Houghton M. Law JLM, et al. Among authors: tyrrell dl. Vaccine. 2021 Sep 24;39(40):5769-5779. doi: 10.1016/j.vaccine.2021.08.081. Epub 2021 Aug 26. Vaccine. 2021. PMID: 34481699 Free PMC article.
Progress toward approval of an HCV vaccine.
Law JL, Logan M, Landi A, Tyrrell DL, Houghton M. Law JL, et al. Among authors: tyrrell dl. Can Liver J. 2018 Oct 3;1(3):130-138. doi: 10.3138/canlivj.2018.0010. eCollection 2018 Summer. Can Liver J. 2018. PMID: 35991323 Free PMC article. Review.
227 results