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Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7.
Tan JY, Vance KW, Varela MA, Sirey T, Watson LM, Curtis HJ, Marinello M, Alves S, Steinkraus B, Cooper S, Nesterova T, Brockdorff N, Fulga T, Brice A, Sittler A, Oliver PL, Wood MJ, Ponting CP, Marques AC. Tan JY, et al. Among authors: brice a. Nat Struct Mol Biol. 2014 Nov;21(11):955-961. doi: 10.1038/nsmb.2902. Epub 2014 Oct 12. Nat Struct Mol Biol. 2014. PMID: 25306109 Free PMC article.
The autophagy/lysosome pathway is impaired in SCA7 patients and SCA7 knock-in mice.
Alves S, Cormier-Dequaire F, Marinello M, Marais T, Muriel MP, Beaumatin F, Charbonnier-Beaupel F, Tahiri K, Seilhean D, El Hachimi K, Ruberg M, Stevanin G, Barkats M, den Dunnen W, Priault M, Brice A, Durr A, Corvol JC, Sittler A. Alves S, et al. Among authors: brice a. Acta Neuropathol. 2014 Nov;128(5):705-22. doi: 10.1007/s00401-014-1289-8. Epub 2014 May 24. Acta Neuropathol. 2014. PMID: 24859968
Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins.
Alves S, Marais T, Biferi MG, Furling D, Marinello M, El Hachimi K, Cartier N, Ruberg M, Stevanin G, Brice A, Barkats M, Sittler A. Alves S, et al. Among authors: brice a. Mol Neurodegener. 2016 Jul 28;11(1):58. doi: 10.1186/s13024-016-0123-2. Mol Neurodegener. 2016. PMID: 27465358 Free PMC article.
1,097 results