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Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.
Hilliard JJ, Datta V, Tkaczyk C, Hamilton M, Sadowska A, Jones-Nelson O, O'Day T, Weiss WJ, Szarka S, Nguyen V, Prokai L, Suzich J, Stover CK, Sellman BR. Hilliard JJ, et al. Among authors: tkaczyk c. Antimicrob Agents Chemother. 2015 Jan;59(1):299-309. doi: 10.1128/AAC.03918-14. Epub 2014 Oct 27. Antimicrob Agents Chemother. 2015. PMID: 25348518 Free PMC article.
Identification of anti-alpha toxin monoclonal antibodies that reduce the severity of Staphylococcus aureus dermonecrosis and exhibit a correlation between affinity and potency.
Tkaczyk C, Hua L, Varkey R, Shi Y, Dettinger L, Woods R, Barnes A, MacGill RS, Wilson S, Chowdhury P, Stover CK, Sellman BR. Tkaczyk C, et al. Clin Vaccine Immunol. 2012 Mar;19(3):377-85. doi: 10.1128/CVI.05589-11. Epub 2012 Jan 11. Clin Vaccine Immunol. 2012. PMID: 22237895 Free PMC article.
Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-alpha toxin antibody fragment and alpha toxin.
Oganesyan V, Barnes A, Tkaczyk C, Ferguson A, Wu H, Dall'Acqua WF. Oganesyan V, et al. Among authors: tkaczyk c. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):302-5. doi: 10.1107/S1744309113002881. Epub 2013 Feb 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013. PMID: 23519809 Free PMC article.
Effects of linezolid on suppressing in vivo production of staphylococcal toxins and improving survival outcomes in a rabbit model of methicillin-resistant Staphylococcus aureus necrotizing pneumonia.
Diep BA, Afasizheva A, Le HN, Kajikawa O, Matute-Bello G, Tkaczyk C, Sellman B, Badiou C, Lina G, Chambers HF. Diep BA, et al. Among authors: tkaczyk c. J Infect Dis. 2013 Jul;208(1):75-82. doi: 10.1093/infdis/jit129. Epub 2013 Mar 26. J Infect Dis. 2013. PMID: 23532096 Free PMC article.
Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia.
Hua L, Hilliard JJ, Shi Y, Tkaczyk C, Cheng LI, Yu X, Datta V, Ren S, Feng H, Zinsou R, Keller A, O'Day T, Du Q, Cheng L, Damschroder M, Robbie G, Suzich J, Stover CK, Sellman BR. Hua L, et al. Among authors: tkaczyk c. Antimicrob Agents Chemother. 2014;58(2):1108-17. doi: 10.1128/AAC.02190-13. Epub 2013 Dec 2. Antimicrob Agents Chemother. 2014. PMID: 24295977 Free PMC article.
Mechanisms of neutralization of a human anti-α-toxin antibody.
Oganesyan V, Peng L, Damschroder MM, Cheng L, Sadowska A, Tkaczyk C, Sellman BR, Wu H, Dall'Acqua WF. Oganesyan V, et al. Among authors: tkaczyk c. J Biol Chem. 2014 Oct 24;289(43):29874-80. doi: 10.1074/jbc.M114.601328. Epub 2014 Sep 10. J Biol Chem. 2014. PMID: 25210036 Free PMC article.
Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections.
Cohen TS, Hilliard JJ, Jones-Nelson O, Keller AE, O'Day T, Tkaczyk C, DiGiandomenico A, Hamilton M, Pelletier M, Wang Q, Diep BA, Le VT, Cheng L, Suzich J, Stover CK, Sellman BR. Cohen TS, et al. Among authors: tkaczyk c. Sci Transl Med. 2016 Mar 9;8(329):329ra31. doi: 10.1126/scitranslmed.aad9922. Sci Transl Med. 2016. PMID: 26962155
Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893.
Tabor DE, Yu L, Mok H, Tkaczyk C, Sellman BR, Wu Y, Oganesyan V, Slidel T, Jafri H, McCarthy M, Bradford P, Esser MT. Tabor DE, et al. Among authors: tkaczyk c. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5312-21. doi: 10.1128/AAC.00357-16. Print 2016 Sep. Antimicrob Agents Chemother. 2016. PMID: 27324766 Free PMC article.
74 results