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Page 1
Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors.
Springuel L, Hornakova T, Losdyck E, Lambert F, Leroy E, Constantinescu SN, Flex E, Tartaglia M, Knoops L, Renauld JC. Springuel L, et al. Among authors: constantinescu sn. Blood. 2014 Dec 18;124(26):3924-31. doi: 10.1182/blood-2014-05-576652. Epub 2014 Oct 28. Blood. 2014. PMID: 25352124 Free article.
JAK2, the JAK2 V617F mutant and cytokine receptors.
Staerk J, Kallin A, Royer Y, Diaconu CC, Dusa A, Demoulin JB, Vainchenker W, Constantinescu SN. Staerk J, et al. Among authors: constantinescu sn. Pathol Biol (Paris). 2007 Mar;55(2):88-91. doi: 10.1016/j.patbio.2006.06.003. Epub 2006 Aug 14. Pathol Biol (Paris). 2007. PMID: 16904848 Review.
JAK kinases overexpression promotes in vitro cell transformation.
Knoops L, Hornakova T, Royer Y, Constantinescu SN, Renauld JC. Knoops L, et al. Among authors: constantinescu sn. Oncogene. 2008 Mar 6;27(11):1511-9. doi: 10.1038/sj.onc.1210800. Epub 2007 Sep 17. Oncogene. 2008. PMID: 17873904
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.
Wernig G, Gonneville JR, Crowley BJ, Rodrigues MS, Reddy MM, Hudon HE, Walz C, Reiter A, Podar K, Royer Y, Constantinescu SN, Tomasson MH, Griffin JD, Gilliland DG, Sattler M. Wernig G, et al. Among authors: constantinescu sn. Blood. 2008 Apr 1;111(7):3751-9. doi: 10.1182/blood-2007-07-102186. Epub 2008 Jan 23. Blood. 2008. PMID: 18216297 Free PMC article.
Mining for JAK-STAT mutations in cancer.
Constantinescu SN, Girardot M, Pecquet C. Constantinescu SN, et al. Trends Biochem Sci. 2008 Mar;33(3):122-31. doi: 10.1016/j.tibs.2007.12.002. Trends Biochem Sci. 2008. PMID: 18291658 Review.
Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia.
Flex E, Petrangeli V, Stella L, Chiaretti S, Hornakova T, Knoops L, Ariola C, Fodale V, Clappier E, Paoloni F, Martinelli S, Fragale A, Sanchez M, Tavolaro S, Messina M, Cazzaniga G, Camera A, Pizzolo G, Tornesello A, Vignetti M, Battistini A, Cavé H, Gelb BD, Renauld JC, Biondi A, Constantinescu SN, Foà R, Tartaglia M. Flex E, et al. Among authors: constantinescu sn. J Exp Med. 2008 Apr 14;205(4):751-8. doi: 10.1084/jem.20072182. Epub 2008 Mar 24. J Exp Med. 2008. PMID: 18362173 Free PMC article.
220 results