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First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors.
Sarker D, Ang JE, Baird R, Kristeleit R, Shah K, Moreno V, Clarke PA, Raynaud FI, Levy G, Ware JA, Mazina K, Lin R, Wu J, Fredrickson J, Spoerke JM, Lackner MR, Yan Y, Friedman LS, Kaye SB, Derynck MK, Workman P, de Bono JS. Sarker D, et al. Among authors: raynaud fi. Clin Cancer Res. 2015 Jan 1;21(1):77-86. doi: 10.1158/1078-0432.CCR-14-0947. Epub 2014 Nov 4. Clin Cancer Res. 2015. PMID: 25370471 Free PMC article. Clinical Trial.
Phase I study of oral JM216 given twice daily.
Beale P, Raynaud F, Hanwell J, Berry C, Moore S, Odell D, Judson I. Beale P, et al. Cancer Chemother Pharmacol. 1998;42(2):142-8. doi: 10.1007/s002800050797. Cancer Chemother Pharmacol. 1998. PMID: 9654114 Clinical Trial.
Validation of liquid chromatography assay for the quantitation of (Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]propionic acid (SU006668) in human plasma and its application to a phase I clinical trial.
Asad Y, Cropp G, Adams A, O'Donnell A, Raynaud F, Judson I, Workman P. Asad Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Feb 25;785(1):175-86. doi: 10.1016/s1570-0232(02)00912-1. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 12535850 Clinical Trial.
191 results