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A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory.
Swadling L, Capone S, Antrobus RD, Brown A, Richardson R, Newell EW, Halliday J, Kelly C, Bowen D, Fergusson J, Kurioka A, Ammendola V, Del Sorbo M, Grazioli F, Esposito ML, Siani L, Traboni C, Hill A, Colloca S, Davis M, Nicosia A, Cortese R, Folgori A, Klenerman P, Barnes E. Swadling L, et al. Among authors: folgori a. Sci Transl Med. 2014 Nov 5;6(261):261ra153. doi: 10.1126/scitranslmed.3009185. Sci Transl Med. 2014. PMID: 25378645 Free PMC article. Clinical Trial.
Identification of disease-specific epitopes.
Folgori A, Luzzago A, Monaci P, Nicosia A, Cortese R, Felici F. Folgori A, et al. Methods Mol Biol. 1998;87:195-208. doi: 10.1385/0-89603-392-9:195. Methods Mol Biol. 1998. PMID: 9523273 No abstract available.
Mimotopes of the hyper variable region 1 of the hepatitis C virus induce cross-reactive antibodies directed against discontinuous epitopes.
Roccasecca R, Folgori A, Ercole BB, Puntoriero G, Lahm A, Zucchelli S, Tafi R, Pezzanera M, Galfre G, Tramontano A, Mondelli MU, Pessi A, Nicosia A, Cortese R, Meola A. Roccasecca R, et al. Among authors: folgori a. Mol Immunol. 2001 Dec;38(6):485-92. doi: 10.1016/s0161-5890(01)00084-0. Mol Immunol. 2001. PMID: 11741698
Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance.
Spada E, Mele A, Berton A, Ruggeri L, Ferrigno L, Garbuglia AR, Perrone MP, Girelli G, Del Porto P, Piccolella E, Mondelli MU, Amoroso P, Cortese R, Nicosia A, Vitelli A, Folgori A. Spada E, et al. Among authors: folgori a. Gut. 2004 Nov;53(11):1673-81. doi: 10.1136/gut.2003.037788. Gut. 2004. PMID: 15479691 Free PMC article.
A novel adenovirus type 6 (Ad6)-based hepatitis C virus vector that overcomes preexisting anti-ad5 immunity and induces potent and broad cellular immune responses in rhesus macaques.
Capone S, Meola A, Ercole BB, Vitelli A, Pezzanera M, Ruggeri L, Davies ME, Tafi R, Santini C, Luzzago A, Fu TM, Bett A, Colloca S, Cortese R, Nicosia A, Folgori A. Capone S, et al. Among authors: folgori a. J Virol. 2006 Feb;80(4):1688-99. doi: 10.1128/JVI.80.4.1688-1699.2006. J Virol. 2006. PMID: 16439526 Free PMC article.
90 results