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Combination treatment with meropenem plus levofloxacin is synergistic against Pseudomonas aeruginosa infection in a murine model of pneumonia.
Louie A, Liu W, VanGuilder M, Neely MN, Schumitzky A, Jelliffe R, Fikes S, Kurhanewicz S, Robbins N, Brown D, Baluya D, Drusano GL. Louie A, et al. Among authors: robbins n. J Infect Dis. 2015 Apr 15;211(8):1326-33. doi: 10.1093/infdis/jiu603. Epub 2014 Oct 31. J Infect Dis. 2015. PMID: 25362196 Free PMC article.
Chemoproteomic Profiling of C. albicans for Characterization of Anti-fungal Kinase Inhibitors.
Shirley DJ, Nandakumar M, Cabrera A, Yiu B, Puumala E, Liu Z, Robbins N, Whitesell L, Smith JL, Lyons SP, Mordant AL, Herring LE, Graves LM, Couñago RM, Drewry DH, Cowen LE, Willson TM. Shirley DJ, et al. Among authors: robbins n. bioRxiv [Preprint]. 2025 Jan 10:2025.01.10.632200. doi: 10.1101/2025.01.10.632200. bioRxiv. 2025. PMID: 39829896 Free PMC article. Preprint.
Butyrolactol A is a phospholipid flippase inhibitor that potentiates the bioactivity of caspofungin against resistant fungi.
Chen X, Duan HD, Hoy MJ, Koteva K, Spitzer M, Guitor AK, Puumala E, Hu G, Yiu B, Chou S, Bian Z, Guo ABY, Sun S, Robbins N, Cook MA, Truant R, MacNeil LT, Brown ED, Kronstad JW, Cowen LE, Heitman J, Li H, Wright GD. Chen X, et al. Among authors: robbins n. bioRxiv [Preprint]. 2025 Jan 6:2025.01.06.630955. doi: 10.1101/2025.01.06.630955. bioRxiv. 2025. PMID: 39829750 Free PMC article. Preprint.
Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy.
Puumala E, Nabeela S, Thornburg CC, Grkovic T, Uppuluri P, Whitesell L, O'Keefe BR, Robbins N, Cowen LE. Puumala E, et al. Among authors: robbins n. Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0119424. doi: 10.1128/aac.01194-24. Epub 2024 Sep 26. Antimicrob Agents Chemother. 2024. PMID: 39324798 Free PMC article.
Addendum: A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.
MacAlpine J, Daniel-Ivad M, Liu Z, Yano J, Revie NM, Todd RT, Stogios PJ, Sanchez H, O'Meara TR, Tompkins TA, Savchenko A, Selmecki A, Veri AO, Andes DR, Fidel PL Jr, Robbins N, Nodwell J, Whitesell L, Cowen LE. MacAlpine J, et al. Among authors: robbins n. Nat Commun. 2024 Aug 1;15(1):6440. doi: 10.1038/s41467-024-50740-z. Nat Commun. 2024. PMID: 39090082 Free PMC article. No abstract available.
282 results