Wang GG - Search Results

1

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.

Xu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Allison DF, Cai L, Rockowitz S, Liu S, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, Zheng D, Jin J, Wang GG. Xu B, et al. Among authors: wang gg. Blood. 2015 Jan 8;125(2):346-57. doi: 10.1182/blood-2014-06-581082. Epub 2014 Nov 13. Blood. 2015. PMID: 25395428 Free PMC article.

2

An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting.

Cai L, Rothbart SB, Lu R, Xu B, Chen WY, Tripathy A, Rockowitz S, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J, Wang GG. Cai L, et al. Among authors: wang gg. Mol Cell. 2013 Feb 7;49(3):571-82. doi: 10.1016/j.molcel.2012.11.026. Epub 2012 Dec 27. Mol Cell. 2013. PMID: 23273982 Free PMC article.

3

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, Roth BL, Brown PJ, Frye SV, Arrowsmith CH, Hahn KM, Wang GG, Vedadi M, Jin J. Konze KD, et al. Among authors: wang gg. ACS Chem Biol. 2013;8(6):1324-34. doi: 10.1021/cb400133j. Epub 2013 Apr 24. ACS Chem Biol. 2013. PMID: 23614352 Free PMC article.

4

Polycomb genes, miRNA, and their deregulation in B-cell malignancies.

Wang GG, Konze KD, Tao J. Wang GG, et al. Blood. 2015 Feb 19;125(8):1217-25. doi: 10.1182/blood-2014-10-606822. Epub 2015 Jan 7. Blood. 2015. PMID: 25568352 Free PMC article. Review.

5

Targeting EZH2 and PRC2 dependence as novel anticancer therapy.

Xu B, Konze KD, Jin J, Wang GG. Xu B, et al. Among authors: wang gg. Exp Hematol. 2015 Aug;43(8):698-712. doi: 10.1016/j.exphem.2015.05.001. Epub 2015 May 28. Exp Hematol. 2015. PMID: 26027790 Free PMC article. Review.

6

An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1.

Zhang ZM, Rothbart SB, Allison DF, Cai Q, Harrison JS, Li L, Wang Y, Strahl BD, Wang GG, Song J. Zhang ZM, et al. Among authors: wang gg, wang y. Cell Rep. 2015 Sep 1;12(9):1400-6. doi: 10.1016/j.celrep.2015.07.046. Epub 2015 Aug 20. Cell Rep. 2015. PMID: 26299963 Free PMC article.

7

Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.

Lu R, Wang P, Parton T, Zhou Y, Chrysovergis K, Rockowitz S, Chen WY, Abdel-Wahab O, Wade PA, Zheng D, Wang GG. Lu R, et al. Among authors: wang gg, wang p. Cancer Cell. 2016 Jul 11;30(1):92-107. doi: 10.1016/j.ccell.2016.05.008. Epub 2016 Jun 23. Cancer Cell. 2016. PMID: 27344947 Free PMC article.

8

The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells.

Xu B, Cai L, Butler JM, Chen D, Lu X, Allison DF, Lu R, Rafii S, Parker JS, Zheng D, Wang GG. Xu B, et al. Among authors: wang gg. Stem Cell Reports. 2018 Mar 13;10(3):675-683. doi: 10.1016/j.stemcr.2018.01.020. Epub 2018 Feb 15. Stem Cell Reports. 2018. PMID: 29456179 Free PMC article.

9

ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer.

Cai L, Tsai YH, Wang P, Wang J, Li D, Fan H, Zhao Y, Bareja R, Lu R, Wilson EM, Sboner A, Whang YE, Zheng D, Parker JS, Earp HS, Wang GG. Cai L, et al. Among authors: wang gg, wang j, wang p. Mol Cell. 2018 Oct 18;72(2):341-354.e6. doi: 10.1016/j.molcel.2018.08.029. Epub 2018 Sep 27. Mol Cell. 2018. PMID: 30270106 Free PMC article.

10

A Model System for Studying the DNMT3A Hotspot Mutation (DNMT3A^R882) Demonstrates a Causal Relationship between Its Dominant-Negative Effect and Leukemogenesis.

Lu R, Wang J, Ren Z, Yin J, Wang Y, Cai L, Wang GG. Lu R, et al. Among authors: wang gg, wang j, wang y. Cancer Res. 2019 Jul 15;79(14):3583-3594. doi: 10.1158/0008-5472.CAN-18-3275. Epub 2019 Jun 4. Cancer Res. 2019. PMID: 31164355 Free PMC article.

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