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Derivation of ligands for the complement C3a receptor from the C-terminus of C5a.
Halai R, Bellows-Peterson ML, Branchett W, Smadbeck J, Kieslich CA, Croker DE, Cooper MA, Morikis D, Woodruff TM, Floudas CA, Monk PN. Halai R, et al. Among authors: floudas ca. Eur J Pharmacol. 2014 Dec 15;745:176-81. doi: 10.1016/j.ejphar.2014.10.041. Epub 2014 Oct 30. Eur J Pharmacol. 2014. PMID: 25446428 Free PMC article.
Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling.
Croker DE, Monk PN, Halai R, Kaeslin G, Schofield Z, Wu MC, Clark RJ, Blaskovich MA, Morikis D, Floudas CA, Cooper MA, Woodruff TM. Croker DE, et al. Among authors: floudas ca. Immunol Cell Biol. 2016 Sep;94(8):787-95. doi: 10.1038/icb.2016.43. Epub 2016 Apr 25. Immunol Cell Biol. 2016. PMID: 27108698 Free article.
A new generation of potent complement inhibitors of the Compstatin family.
López de Victoria A, Gorham RD Jr, Bellows-Peterson ML, Ling J, Lo DD, Floudas CA, Morikis D. López de Victoria A, et al. Among authors: floudas ca. Chem Biol Drug Des. 2011 Jun;77(6):431-40. doi: 10.1111/j.1747-0285.2011.01111.x. Epub 2011 Apr 26. Chem Biol Drug Des. 2011. PMID: 21352502 Free PMC article.
Molecular dynamics in drug design: new generations of compstatin analogs.
Tamamis P, López de Victoria A, Gorham RD Jr, Bellows-Peterson ML, Pierou P, Floudas CA, Morikis D, Archontis G. Tamamis P, et al. Among authors: floudas ca. Chem Biol Drug Des. 2012 May;79(5):703-18. doi: 10.1111/j.1747-0285.2012.01324.x. Epub 2012 Feb 9. Chem Biol Drug Des. 2012. PMID: 22233517 Free PMC article.
Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures.
Gorham RD Jr, Forest DL, Tamamis P, López de Victoria A, Kraszni M, Kieslich CA, Banna CD, Bellows-Peterson ML, Larive CK, Floudas CA, Archontis G, Johnson LV, Morikis D. Gorham RD Jr, et al. Among authors: floudas ca. Exp Eye Res. 2013 Nov;116:96-108. doi: 10.1016/j.exer.2013.07.023. Epub 2013 Aug 15. Exp Eye Res. 2013. PMID: 23954241 Free PMC article.
Forcefield_NCAA: ab initio charge parameters to aid in the discovery and design of therapeutic proteins and peptides with unnatural amino acids and their application to complement inhibitors of the compstatin family.
Khoury GA, Smadbeck J, Tamamis P, Vandris AC, Kieslich CA, Floudas CA. Khoury GA, et al. Among authors: floudas ca. ACS Synth Biol. 2014 Dec 19;3(12):855-69. doi: 10.1021/sb400168u. Epub 2014 Jan 14. ACS Synth Biol. 2014. PMID: 24932669 Free PMC article.
New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics.
Gorham RD Jr, Forest DL, Khoury GA, Smadbeck J, Beecher CN, Healy ED, Tamamis P, Archontis G, Larive CK, Floudas CA, Radeke MJ, Johnson LV, Morikis D. Gorham RD Jr, et al. Among authors: floudas ca. J Med Chem. 2015 Jan 22;58(2):814-26. doi: 10.1021/jm501345y. Epub 2014 Dec 29. J Med Chem. 2015. PMID: 25494040 Free PMC article.
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