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Systematic evaluation of non-animal test methods for skin sensitisation safety assessment.
Reisinger K, Hoffmann S, Alépée N, Ashikaga T, Barroso J, Elcombe C, Gellatly N, Galbiati V, Gibbs S, Groux H, Hibatallah J, Keller D, Kern P, Klaric M, Kolle S, Kuehnl J, Lambrechts N, Lindstedt M, Millet M, Martinozzi-Teissier S, Natsch A, Petersohn D, Pike I, Sakaguchi H, Schepky A, Tailhardat M, Templier M, van Vliet E, Maxwell G. Reisinger K, et al. Among authors: hoffmann s. Toxicol In Vitro. 2015 Feb;29(1):259-70. doi: 10.1016/j.tiv.2014.10.018. Toxicol In Vitro. 2015. PMID: 25448812 Free article.
A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.
Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, Goethem FV, Vassallo M, Vinardell P, Zuang V. Scott L, et al. Among authors: hoffmann s. Toxicol In Vitro. 2010 Feb;24(1):1-9. doi: 10.1016/j.tiv.2009.05.019. Epub 2009 May 31. Toxicol In Vitro. 2010. PMID: 19490935 Review.
Regulatory assessment of in vitro skin corrosion and irritation data within the European framework: Workshop recommendations.
Eskes C, Detappe V, Koëter H, Kreysa J, Liebsch M, Zuang V, Amcoff P, Barroso J, Cotovio J, Guest R, Hermann M, Hoffmann S, Masson P, Alépée N, Arce LA, Brüschweiler B, Catone T, Cihak R, Clouzeau J, D'Abrosca F, Delveaux C, Derouette JP, Engelking O, Facchini D, Fröhlicher M, Hofmann M, Hopf N, Molinari J, Oberli A, Ott M, Peter R, Sá-Rocha VM, Schenk D, Tomicic C, Vanparys P, Verdon B, Wallenhorst T, Winkler GC, Depallens O. Eskes C, et al. Among authors: hoffmann s. Regul Toxicol Pharmacol. 2012 Mar;62(2):393-403. doi: 10.1016/j.yrtph.2011.10.015. Epub 2011 Nov 6. Regul Toxicol Pharmacol. 2012. PMID: 22085589
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.
Basketter DA, Clewell H, Kimber I, Rossi A, Blaauboer B, Burrier R, Daneshian M, Eskes C, Goldberg A, Hasiwa N, Hoffmann S, Jaworska J, Knudsen TB, Landsiedel R, Leist M, Locke P, Maxwell G, McKim J, McVey EA, Ouédraogo G, Patlewicz G, Pelkonen O, Roggen E, Rovida C, Ruhdel I, Schwarz M, Schepky A, Schoeters G, Skinner N, Trentz K, Turner M, Vanparys P, Yager J, Zurlo J, Hartung T. Basketter DA, et al. Among authors: hoffmann s. ALTEX. 2012;29(1):3-91. doi: 10.14573/altex.2012.1.003. ALTEX. 2012. PMID: 22307314
Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods.
Adriaens E, Barroso J, Eskes C, Hoffmann S, McNamee P, Alépée N, Bessou-Touya S, De Smedt A, De Wever B, Pfannenbecker U, Tailhardat M, Zuang V. Adriaens E, et al. Among authors: hoffmann s. Arch Toxicol. 2014 Mar;88(3):701-23. doi: 10.1007/s00204-013-1156-8. Epub 2013 Dec 28. Arch Toxicol. 2014. PMID: 24374802 Free PMC article.
Categorization of chemicals according to their relative human skin sensitizing potency.
Basketter DA, Alépée N, Ashikaga T, Barroso J, Gilmour N, Goebel C, Hibatallah J, Hoffmann S, Kern P, Martinozzi-Teissier S, Maxwell G, Reisinger K, Sakaguchi H, Schepky A, Tailhardat M, Templier M. Basketter DA, et al. Among authors: hoffmann s. Dermatitis. 2014 Jan-Feb;25(1):11-21. doi: 10.1097/DER.0000000000000003. Dermatitis. 2014. PMID: 24407057 Review.
Validation study on the Ocular Irritection assay for eye irritation testing.
Eskes C, Hoffmann S, Facchini D, Ulmer R, Wang A, Flego M, Vassallo M, Bufo M, van Vliet E, d'Abrosca F, Wilt N. Eskes C, et al. Among authors: hoffmann s. Toxicol In Vitro. 2014 Aug;28(5):1046-65. doi: 10.1016/j.tiv.2014.02.009. Epub 2014 Mar 15. Toxicol In Vitro. 2014. PMID: 24637247 Free article.
Integrated Testing Strategies (ITS) for safety assessment.
Rovida C, Alépée N, Api AM, Basketter DA, Bois FY, Caloni F, Corsini E, Daneshian M, Eskes C, Ezendam J, Fuchs H, Hayden P, Hegele-Hartung C, Hoffmann S, Hubesch B, Jacobs MN, Jaworska J, Kleensang A, Kleinstreuer N, Lalko J, Landsiedel R, Lebreux F, Luechtefeld T, Locatelli M, Mehling A, Natsch A, Pitchford JW, Prater D, Prieto P, Schepky A, Schüürmann G, Smirnova L, Toole C, van Vliet E, Weisensee D, Hartung T. Rovida C, et al. Among authors: hoffmann s. ALTEX. 2015;32(1):25-40. doi: 10.14573/altex.1411011. Epub 2014 Nov 19. ALTEX. 2015. PMID: 25413849 Free article.
1,808 results