Koakutsu A - Search Results

1

Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels.

Ogiyama T, Inoue M, Honda S, Yamada H, Watanabe T, Gotoh T, Kiso T, Koakutsu A, Kakimoto S, Shishikura J. Ogiyama T, et al. Among authors: koakutsu a. Bioorg Med Chem. 2014 Dec 15;22(24):6899-907. doi: 10.1016/j.bmc.2014.10.020. Epub 2014 Oct 22. Bioorg Med Chem. 2014. PMID: 25456079

2

Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain.

Ogiyama T, Yonezawa K, Inoue M, Watanabe T, Sugano Y, Gotoh T, Kiso T, Koakutsu A, Kakimoto S, Shishikura JI. Ogiyama T, et al. Among authors: koakutsu a. Bioorg Med Chem. 2015 Aug 1;23(15):4624-4637. doi: 10.1016/j.bmc.2015.05.030. Epub 2015 May 27. Bioorg Med Chem. 2015. PMID: 26071371

3

Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability.

Ogiyama T, Yonezawa K, Inoue M, Katayama N, Watanabe T, Yoshimura S, Gotoh T, Kiso T, Koakutsu A, Kakimoto S, Shishikura JI. Ogiyama T, et al. Among authors: koakutsu a. Bioorg Med Chem. 2015 Aug 1;23(15):4638-4648. doi: 10.1016/j.bmc.2015.05.053. Epub 2015 Jun 3. Bioorg Med Chem. 2015. PMID: 26078010

4

Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors.

Nagashima S, Nagata H, Iwata M, Yokota M, Moritomo H, Orita M, Kuromitsu S, Koakutsu A, Ohga K, Takeuchi M, Ohta M, Tsukamoto S. Nagashima S, et al. Among authors: koakutsu a. Bioorg Med Chem. 2008 Jul 1;16(13):6509-21. doi: 10.1016/j.bmc.2008.05.031. Epub 2008 May 17. Bioorg Med Chem. 2008. PMID: 18534856

5

Pharmacological characterization of YM598, an orally active and highly potent selective endothelin ET(A) receptor antagonist.

Yuyama H, Sanagi M, Koakutsu A, Mori M, Fujimori A, Harada H, Sudoh K, Miyata K. Yuyama H, et al. Among authors: koakutsu a. Eur J Pharmacol. 2003 Sep 30;478(1):61-71. doi: 10.1016/j.ejphar.2003.08.031. Eur J Pharmacol. 2003. PMID: 14555186

6

Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist.

Kimura Y, Hatanaka K, Naitou Y, Maeno K, Shimada I, Koakutsu A, Wanibuchi F, Yamaguchi T. Kimura Y, et al. Among authors: koakutsu a. Eur J Pharmacol. 2004 Jan 1;483(1):37-43. doi: 10.1016/j.ejphar.2003.10.004. Eur J Pharmacol. 2004. PMID: 14709324

7

Comparison of intestinal metabolism of CYP3A substrates between rats and humans: application of portal-systemic concentration difference method.

Kadono K, Koakutsu A, Naritomi Y, Terashita S, Tabata K, Teramura T. Kadono K, et al. Among authors: koakutsu a. Xenobiotica. 2014 Jun;44(6):511-21. doi: 10.3109/00498254.2013.869375. Epub 2013 Dec 12. Xenobiotica. 2014. PMID: 24329478

8

The orally active nonpeptide selective endothelin ETA receptor antagonist YM598 prevents and reverses the development of pulmonary hypertension in monocrotaline-treated rats.

Yuyama H, Fujimori A, Sanagi M, Koakutsu A, Sudoh K, Sasamata M, Miyata K. Yuyama H, et al. Among authors: koakutsu a. Eur J Pharmacol. 2004 Aug 2;496(1-3):129-39. doi: 10.1016/j.ejphar.2004.06.021. Eur J Pharmacol. 2004. PMID: 15288584

9

Chronic treatment with olanzapine via a novel infusion pump induces adiposity in male rats.

Shobo M, Yamada H, Koakutsu A, Hamada N, Fujii M, Harada K, Ni K, Matsuoka N. Shobo M, et al. Among authors: koakutsu a. Life Sci. 2011 Apr 25;88(17-18):761-5. doi: 10.1016/j.lfs.2011.02.014. Epub 2011 Feb 25. Life Sci. 2011. PMID: 21356217

10

Effects of selective endothelin ET(A) receptor antagonists on endothelin-1-induced potentiation of cancer pain.

Yuyama H, Koakutsu A, Fujiyasu N, Tanahashi M, Fujimori A, Sato S, Shibasaki K, Tanaka S, Sudoh K, Sasamata M, Miyata K. Yuyama H, et al. Among authors: koakutsu a. Eur J Pharmacol. 2004 May 25;492(2-3):177-82. doi: 10.1016/j.ejphar.2004.04.016. Eur J Pharmacol. 2004. PMID: 15178362

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