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The repressor element 1-silencing transcription factor is a novel molecular target for the neurotoxic effect of the polychlorinated biphenyl mixture aroclor 1254 in neuroblastoma SH-SY5Y cells.
Formisano L, Guida N, Cocco S, Secondo A, Sirabella R, Ulianich L, Paturzo F, Di Renzo G, Canzoniero LM. Formisano L, et al. Among authors: di renzo g. J Pharmacol Exp Ther. 2011 Sep;338(3):997-1003. doi: 10.1124/jpet.111.181289. Epub 2011 Jun 21. J Pharmacol Exp Ther. 2011. PMID: 21693630
NCX1 is a new rest target gene: role in cerebral ischemia.
Formisano L, Guida N, Valsecchi V, Pignataro G, Vinciguerra A, Pannaccione A, Secondo A, Boscia F, Molinaro P, Sisalli MJ, Sirabella R, Casamassa A, Canzoniero LM, Di Renzo G, Annunziato L. Formisano L, et al. Among authors: di renzo g. Neurobiol Dis. 2013 Feb;50:76-85. doi: 10.1016/j.nbd.2012.10.010. Epub 2012 Oct 13. Neurobiol Dis. 2013. PMID: 23069678
Histone deacetylase 4 promotes ubiquitin-dependent proteasomal degradation of Sp3 in SH-SY5Y cells treated with di(2-ethylhexyl)phthalate (DEHP), determining neuronal death.
Guida N, Laudati G, Galgani M, Santopaolo M, Montuori P, Triassi M, Di Renzo G, Canzoniero LM, Formisano L. Guida N, et al. Among authors: di renzo g. Toxicol Appl Pharmacol. 2014 Oct 1;280(1):190-8. doi: 10.1016/j.taap.2014.07.014. Epub 2014 Jul 25. Toxicol Appl Pharmacol. 2014. PMID: 25068794
Extracellular signal-related kinase 2/specificity protein 1/specificity protein 3/repressor element-1 silencing transcription factor pathway is involved in Aroclor 1254-induced toxicity in SH-SY5Y neuronal cells.
Formisano L, Guida N, Laudati G, Boscia F, Esposito A, Secondo A, Di Renzo G, Canzoniero LM. Formisano L, et al. Among authors: di renzo g. J Neurosci Res. 2015 Jan;93(1):167-77. doi: 10.1002/jnr.23464. Epub 2014 Aug 5. J Neurosci Res. 2015. PMID: 25093670
Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism.
Formisano L, Guida N, Valsecchi V, Cantile M, Cuomo O, Vinciguerra A, Laudati G, Pignataro G, Sirabella R, Di Renzo G, Annunziato L. Formisano L, et al. Among authors: di renzo g. J Neurosci. 2015 May 13;35(19):7332-48. doi: 10.1523/JNEUROSCI.2174-14.2015. J Neurosci. 2015. PMID: 25972164 Free PMC article.
The neurotoxicant PCB-95 by increasing the neuronal transcriptional repressor REST down-regulates caspase-8 and increases Ripk1, Ripk3 and MLKL expression determining necroptotic neuronal death.
Guida N, Laudati G, Serani A, Mascolo L, Molinaro P, Montuori P, Di Renzo G, Canzoniero LMT, Formisano L. Guida N, et al. Among authors: di renzo g. Biochem Pharmacol. 2017 Oct 15;142:229-241. doi: 10.1016/j.bcp.2017.06.135. Epub 2017 Jul 1. Biochem Pharmacol. 2017. PMID: 28676433
564 results