Rovira X - Search Results

1

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.

Xue L, Rovira X, Scholler P, Zhao H, Liu J, Pin JP, Rondard P. Xue L, et al. Among authors: rovira x. Nat Chem Biol. 2015 Feb;11(2):134-40. doi: 10.1038/nchembio.1711. Epub 2014 Dec 15. Nat Chem Biol. 2015. PMID: 25503927

2

Modeling the binding and function of metabotropic glutamate receptors.

Rovira X, Roche D, Serra J, Kniazeff J, Pin JP, Giraldo J. Rovira X, et al. J Pharmacol Exp Ther. 2008 May;325(2):443-56. doi: 10.1124/jpet.107.133967. Epub 2008 Feb 20. J Pharmacol Exp Ther. 2008. PMID: 18287211 Free article.

3

The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways.

Rovira X, Pin JP, Giraldo J. Rovira X, et al. Trends Pharmacol Sci. 2010 Jan;31(1):15-21. doi: 10.1016/j.tips.2009.10.008. Epub 2009 Dec 4. Trends Pharmacol Sci. 2010. PMID: 19963287 Review.

4

An allosteric modulator to control endogenous G protein-coupled receptors with light.

Pittolo S, Gómez-Santacana X, Eckelt K, Rovira X, Dalton J, Goudet C, Pin JP, Llobet A, Giraldo J, Llebaria A, Gorostiza P. Pittolo S, et al. Among authors: rovira x. Nat Chem Biol. 2014 Oct;10(10):813-5. doi: 10.1038/nchembio.1612. Epub 2014 Aug 31. Nat Chem Biol. 2014. PMID: 25173999

5

Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor.

Rovira X, Harrak Y, Trapero A, González-Bulnes P, Malhaire F, Pin JP, Goudet C, Giraldo J, Llebaria A. Rovira X, et al. ChemMedChem. 2014 Dec;9(12):2685-98. doi: 10.1002/cmdc.201402190. Epub 2014 Sep 5. ChemMedChem. 2014. PMID: 25196639

6

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors.

Rovira X, Malhaire F, Scholler P, Rodrigo J, Gonzalez-Bulnes P, Llebaria A, Pin JP, Giraldo J, Goudet C. Rovira X, et al. FASEB J. 2015 Jan;29(1):116-30. doi: 10.1096/fj.14-257287. Epub 2014 Oct 23. FASEB J. 2015. PMID: 25342125

7

Allosteric modulation of metabotropic glutamate receptors by chloride ions.

Tora AS, Rovira X, Dione I, Bertrand HO, Brabet I, De Koninck Y, Doyon N, Pin JP, Acher F, Goudet C. Tora AS, et al. Among authors: rovira x. FASEB J. 2015 Oct;29(10):4174-88. doi: 10.1096/fj.14-269746. Epub 2015 Jun 26. FASEB J. 2015. PMID: 26116702

8

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective.

Dalton JA, Lans I, Rovira X, Malhaire F, Gómez-Santacana X, Pittolo S, Gorostiza P, Llebaria A, Goudet C, Pin JP, Giraldo J. Dalton JA, et al. Among authors: rovira x. Curr Neuropharmacol. 2016;14(5):441-54. doi: 10.2174/1570159x13666150407231417. Curr Neuropharmacol. 2016. PMID: 26391742 Free PMC article.

9

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.

Rovira X, Trapero A, Pittolo S, Zussy C, Faucherre A, Jopling C, Giraldo J, Pin JP, Gorostiza P, Goudet C, Llebaria A. Rovira X, et al. Cell Chem Biol. 2016 Aug 18;23(8):929-34. doi: 10.1016/j.chembiol.2016.06.013. Epub 2016 Jul 28. Cell Chem Biol. 2016. PMID: 27478159 Free article.

10

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals.

Gómez-Santacana X, Pittolo S, Rovira X, Lopez M, Zussy C, Dalton JA, Faucherre A, Jopling C, Pin JP, Ciruela F, Goudet C, Giraldo J, Gorostiza P, Llebaria A. Gómez-Santacana X, et al. Among authors: rovira x. ACS Cent Sci. 2017 Jan 25;3(1):81-91. doi: 10.1021/acscentsci.6b00353. Epub 2016 Dec 19. ACS Cent Sci. 2017. PMID: 28149957 Free PMC article.

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