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SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.
Hernanda PY, Chen K, Das AM, Sideras K, Wang W, Li J, Cao W, Bots SJ, Kodach LL, de Man RA, Ijzermans JN, Janssen HL, Stubbs AP, Sprengers D, Bruno MJ, Metselaar HJ, ten Hagen TL, Kwekkeboom J, Peppelenbosch MP, Pan Q. Hernanda PY, et al. Among authors: peppelenbosch mp. Oncogene. 2015 Sep 24;34(39):5055-68. doi: 10.1038/onc.2014.425. Epub 2014 Dec 22. Oncogene. 2015. PMID: 25531314
The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.
Kodach LL, Wiercinska E, de Miranda NF, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, van Noesel CJ, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJ, Hardwick JC. Kodach LL, et al. Among authors: peppelenbosch mp. Gastroenterology. 2008 May;134(5):1332-41. doi: 10.1053/j.gastro.2008.02.059. Epub 2008 Mar 4. Gastroenterology. 2008. PMID: 18471510
Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.
Kodach LL, Jacobs RJ, Voorneveld PW, Wildenberg ME, Verspaget HW, van Wezel T, Morreau H, Hommes DW, Peppelenbosch MP, van den Brink GR, Hardwick JC. Kodach LL, et al. Among authors: peppelenbosch mp. Gut. 2011 Nov;60(11):1544-53. doi: 10.1136/gut.2011.237495. Epub 2011 May 6. Gut. 2011. PMID: 21551187
550 results