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Delayed oral toxicity from long-term vemurafenib therapy.
Lloyd-Lavery A, Hodgson T, Coupe N, Bond S, Shah K, Espinosa O, Payne MJ, Middleton MR, Matin RN. Lloyd-Lavery A, et al. Among authors: coupe n. Br J Dermatol. 2016 May;174(5):1159-60. doi: 10.1111/bjd.14457. Epub 2016 Mar 30. Br J Dermatol. 2016. PMID: 26853702 No abstract available.
A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer.
Eyre TA, Collins GP, Gupta A, Coupe N, Sheikh S, Whittaker J, Wang LM, Campo L, Soilleux E, Tysoe F, Cousins R, La Thangue N, Folkes LK, Stratford MRL, Kerr D, Middleton MR. Eyre TA, et al. Among authors: coupe n. Cancer. 2019 Jan 1;125(1):99-108. doi: 10.1002/cncr.31791. Epub 2018 Oct 17. Cancer. 2019. PMID: 30332497 Free article. Clinical Trial.
sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients.
Fane ME, Ecker BL, Kaur A, Marino GE, Alicea GM, Douglass SM, Chhabra Y, Webster MR, Marshall A, Colling R, Espinosa O, Coupe N, Maroo N, Campo L, Middleton MR, Corrie P, Xu X, Karakousis GC, Weeraratna AT. Fane ME, et al. Among authors: coupe n. Clin Cancer Res. 2020 Nov 1;26(21):5709-5719. doi: 10.1158/1078-0432.CCR-20-0446. Clin Cancer Res. 2020. PMID: 33097493 Free PMC article.
Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles.
Ye W, Olsson-Brown A, Watson RA, Cheung VTF, Morgan RD, Nassiri I, Cooper R, Taylor CA, Akbani U, Brain O, Matin RN, Coupe N, Middleton MR, Coles M, Sacco JJ, Payne MJ, Fairfax BP. Ye W, et al. Among authors: coupe n. Br J Cancer. 2021 May;124(10):1661-1669. doi: 10.1038/s41416-021-01310-3. Epub 2021 Mar 15. Br J Cancer. 2021. PMID: 33723392 Free PMC article.
Interferon-Gamma-Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor-Colitis.
Sasson SC, Slevin SM, Cheung VTF, Nassiri I, Olsson-Brown A, Fryer E, Ferreira RC, Trzupek D, Gupta T, Al-Hillawi L, Issaias ML, Easton A, Campo L, FitzPatrick MEB, Adams J, Chitnis M, Protheroe A, Tuthill M, Coupe N, Simmons A, Payne M, Middleton MR, Travis SPL; Oxford Inflammatory Bowel Disease Cohort Investigators; Fairfax BP, Klenerman P, Brain O. Sasson SC, et al. Among authors: coupe n. Gastroenterology. 2021 Oct;161(4):1229-1244.e9. doi: 10.1053/j.gastro.2021.06.025. Epub 2021 Jun 17. Gastroenterology. 2021. PMID: 34147519 Free PMC article.
WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma.
Coupe N, Guo L, Bridges E, Campo L, Espinosa O, Colling R, Marshall A, Nandakumar A, van Stiphout R, Buffa FM, Corrie PG, Middleton MR, Macaulay VM. Coupe N, et al. Cell Oncol (Dordr). 2023 Apr;46(2):391-407. doi: 10.1007/s13402-022-00757-7. Epub 2022 Dec 21. Cell Oncol (Dordr). 2023. PMID: 36539575 Free PMC article.
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma.
Taylor CA, Watson RA, Tong O, Ye W, Nassiri I, Gilchrist JJ, de Los Aires AV, Sharma PK, Koturan S, Cooper RA, Woodcock VK, Jungkurth E, Shine B, Coupe N, Payne MJ, Church DN, Naranbhai V, Groha S, Emery P, Mankia K, Freedman ML, Choueiri TK, Middleton MR, Gusev A, Fairfax BP. Taylor CA, et al. Among authors: coupe n. Nat Med. 2022 Dec;28(12):2592-2600. doi: 10.1038/s41591-022-02095-5. Epub 2022 Dec 16. Nat Med. 2022. PMID: 36526722 Free PMC article.
Toxicities associated with checkpoint inhibitors-an overview.
Spiers L, Coupe N, Payne M. Spiers L, et al. Among authors: coupe n. Rheumatology (Oxford). 2019 Dec 1;58(Suppl 7):vii7-vii16. doi: 10.1093/rheumatology/kez418. Rheumatology (Oxford). 2019. PMID: 31816085 Free PMC article. Review.
48 results