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Page 1
The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride.
Bazúa-Valenti S, Chávez-Canales M, Rojas-Vega L, González-Rodríguez X, Vázquez N, Rodríguez-Gama A, Argaiz ER, Melo Z, Plata C, Ellison DH, García-Valdés J, Hadchouel J, Gamba G. Bazúa-Valenti S, et al. Among authors: hadchouel j. J Am Soc Nephrol. 2015 Aug;26(8):1781-6. doi: 10.1681/ASN.2014050470. Epub 2014 Dec 26. J Am Soc Nephrol. 2015. PMID: 25542968 Free PMC article.
WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J. Chávez-Canales M, et al. Among authors: hadchouel j. Hypertension. 2014 Nov;64(5):1047-53. doi: 10.1161/HYPERTENSIONAHA.114.04036. Epub 2014 Aug 11. Hypertension. 2014. PMID: 25113964 Free PMC article.
With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.
Mercado A, de Los Heros P, Melo Z, Chávez-Canales M, Murillo-de-Ozores AR, Moreno E, Bazúa-Valenti S, Vázquez N, Hadchouel J, Gamba G. Mercado A, et al. Among authors: hadchouel j. Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C54-66. doi: 10.1152/ajpcell.00193.2015. Epub 2016 May 11. Am J Physiol Cell Physiol. 2016. PMID: 27170636 Free PMC article.
Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC.
Argaiz ER, Chavez-Canales M, Ostrosky-Frid M, Rodríguez-Gama A, Vázquez N, Gonzalez-Rodriguez X, Garcia-Valdes J, Hadchouel J, Ellison D, Gamba G. Argaiz ER, et al. Among authors: hadchouel j. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F734-F745. doi: 10.1152/ajprenal.00145.2018. Epub 2018 May 30. Am J Physiol Renal Physiol. 2018. PMID: 29846116 Free PMC article.
Ovarian hormones and prolactin increase renal NaCl cotransporter phosphorylation.
Rojas-Vega L, Reyes-Castro LA, Ramírez V, Bautista-Pérez R, Rafael C, Castañeda-Bueno M, Meade P, de Los Heros P, Arroyo-Garza I, Bernard V, Binart N, Bobadilla NA, Hadchouel J, Zambrano E, Gamba G. Rojas-Vega L, et al. Among authors: hadchouel j. Am J Physiol Renal Physiol. 2015 Apr 15;308(8):F799-808. doi: 10.1152/ajprenal.00447.2014. Epub 2015 Jan 13. Am J Physiol Renal Physiol. 2015. PMID: 25587121 Free article.
Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel-Khalek W, Argaiz ER, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, Girerd X, O'Shaugnessy K, Mulatero P, Roussey G, Tack I, Unwin R, Vargas-Poussou R, Staub O, Grimm R, Welling PA, Gamba G, Clauser E, Hadchouel J, Jeunemaitre X. Louis-Dit-Picard H, et al. Among authors: hadchouel j. J Clin Invest. 2020 Dec 1;130(12):6379-6394. doi: 10.1172/JCI94171. J Clin Invest. 2020. PMID: 32790646 Free PMC article.
58 results