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Page 1
The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride.
Bazúa-Valenti S, Chávez-Canales M, Rojas-Vega L, González-Rodríguez X, Vázquez N, Rodríguez-Gama A, Argaiz ER, Melo Z, Plata C, Ellison DH, García-Valdés J, Hadchouel J, Gamba G. Bazúa-Valenti S, et al. J Am Soc Nephrol. 2015 Aug;26(8):1781-6. doi: 10.1681/ASN.2014050470. Epub 2014 Dec 26. J Am Soc Nephrol. 2015. PMID: 25542968 Free PMC article.
WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J. Chávez-Canales M, et al. Hypertension. 2014 Nov;64(5):1047-53. doi: 10.1161/HYPERTENSIONAHA.114.04036. Epub 2014 Aug 11. Hypertension. 2014. PMID: 25113964 Free PMC article.
Ovarian hormones and prolactin increase renal NaCl cotransporter phosphorylation.
Rojas-Vega L, Reyes-Castro LA, Ramírez V, Bautista-Pérez R, Rafael C, Castañeda-Bueno M, Meade P, de Los Heros P, Arroyo-Garza I, Bernard V, Binart N, Bobadilla NA, Hadchouel J, Zambrano E, Gamba G. Rojas-Vega L, et al. Am J Physiol Renal Physiol. 2015 Apr 15;308(8):F799-808. doi: 10.1152/ajprenal.00447.2014. Epub 2015 Jan 13. Am J Physiol Renal Physiol. 2015. PMID: 25587121 Free article.
Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort.
Rojas-Vega L, Jiménez-Vega AR, Bazúa-Valenti S, Arroyo-Garza I, Jiménez JV, Gómez-Ocádiz R, Carrillo-Pérez DL, Moreno E, Morales-Buenrostro LE, Alberú J, Gamba G. Rojas-Vega L, et al. Am J Physiol Renal Physiol. 2015 Nov 15;309(10):F836-42. doi: 10.1152/ajprenal.00326.2015. Epub 2015 Sep 2. Am J Physiol Renal Physiol. 2015. PMID: 26336164 Free article.
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.
Castañeda-Bueno M, Arroyo JP, Zhang J, Puthumana J, Yarborough O 3rd, Shibata S, Rojas-Vega L, Gamba G, Rinehart J, Lifton RP. Castañeda-Bueno M, et al. Among authors: rojas vega l. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E879-E886. doi: 10.1073/pnas.1620315114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096417 Free PMC article.
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