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Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development.
Buettner R, Corzano R, Rashid R, Lin J, Senthil M, Hedvat M, Schroeder A, Mao A, Herrmann A, Yim J, Li H, Yuan YC, Yakushijin K, Yakushijin F, Vaidehi N, Moore R, Gugiu G, Lee TD, Yip R, Chen Y, Jove R, Horne D, Williams JC. Buettner R, et al. Among authors: horne d. ACS Chem Biol. 2011 May 20;6(5):432-43. doi: 10.1021/cb100253e. Epub 2011 Feb 16. ACS Chem Biol. 2011. PMID: 21226522 Free PMC article.
Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA.
Ma Y, Kowolik CM, Swiderski PM, Kortylewski M, Yu H, Horne DA, Jove R, Caballero OL, Simpson AJ, Lee FT, Pillay V, Scott AM. Ma Y, et al. ACS Chem Biol. 2011 Sep 16;6(9):962-70. doi: 10.1021/cb200176v. Epub 2011 Jul 26. ACS Chem Biol. 2011. PMID: 21766840 Free PMC article.
Identification of Oct4-activating compounds that enhance reprogramming efficiency.
Li W, Tian E, Chen ZX, Sun G, Ye P, Yang S, Lu D, Xie J, Ho TV, Tsark WM, Wang C, Horne DA, Riggs AD, Yip ML, Shi Y. Li W, et al. Among authors: horne da. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8. doi: 10.1073/pnas.1219181110. Epub 2012 Dec 3. Proc Natl Acad Sci U S A. 2012. PMID: 23213213 Free PMC article.
Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer.
Wen W, Liang W, Wu J, Kowolik CM, Buettner R, Scuto A, Hsieh MY, Hong H, Brown CE, Forman SJ, Horne D, Morgan R, Wakabayashi M, Dellinger TH, Han ES, Yim JH, Jove R. Wen W, et al. Among authors: horne d. Mol Cancer Ther. 2014 Dec;13(12):3037-48. doi: 10.1158/1535-7163.MCT-14-0077. Epub 2014 Oct 15. Mol Cancer Ther. 2014. PMID: 25319391 Free PMC article.
SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMP-dependent Kinase (AMPK)-Mammalian Target of Rapamycin (mTOR) Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells.
Figarola JL, Singhal J, Tompkins JD, Rogers GW, Warden C, Horne D, Riggs AD, Awasthi S, Singhal SS. Figarola JL, et al. Among authors: horne d. J Biol Chem. 2015 Dec 18;290(51):30321-41. doi: 10.1074/jbc.M115.686352. Epub 2015 Nov 3. J Biol Chem. 2015. PMID: 26534958 Free PMC article.
529 results