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Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression.
Böttcher R, Henderson DJ, Dulla K, van Strijp D, Waanders LF, Tevz G, Lehman ML, Merkle D, van Leenders GJ, Baillie GS, Jenster G, Houslay MD, Hoffmann R. Böttcher R, et al. Among authors: hoffmann r. Br J Cancer. 2015 Nov 17;113(10):1502-11. doi: 10.1038/bjc.2015.335. Br J Cancer. 2015. PMID: 26575822 Free PMC article.
The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells.
Henderson DJ, Byrne A, Dulla K, Jenster G, Hoffmann R, Baillie GS, Houslay MD. Henderson DJ, et al. Among authors: hoffmann r. Br J Cancer. 2014 Mar 4;110(5):1278-87. doi: 10.1038/bjc.2014.22. Epub 2014 Feb 11. Br J Cancer. 2014. PMID: 24518597 Free PMC article.
Validation of Cyclic Adenosine Monophosphate Phosphodiesterase-4D7 for its Independent Contribution to Risk Stratification in a Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.
Alves de Inda M, van Strijp D, den Biezen-Timmermans E, van Brussel A, Wrobel J, van Zon H, Vos P, Baillie GS, Tennstedt P, Schlomm T, Houslay MD, Bangma C, Hoffmann R. Alves de Inda M, et al. Among authors: hoffmann r. Eur Urol Focus. 2018 Apr;4(3):376-384. doi: 10.1016/j.euf.2017.05.010. Epub 2017 Jun 13. Eur Urol Focus. 2018. PMID: 28753810 Free article.
2,902 results