Reeve SM - Search Results

1

Protein design algorithms predict viable resistance to an experimental antifolate.

Reeve SM, Gainza P, Frey KM, Georgiev I, Donald BR, Anderson AC. Reeve SM, et al. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):749-54. doi: 10.1073/pnas.1411548112. Epub 2014 Dec 31. Proc Natl Acad Sci U S A. 2015. PMID: 25552560 Free PMC article.

2

Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.

Keshipeddy S, Reeve SM, Anderson AC, Wright DL. Keshipeddy S, et al. Among authors: reeve sm. J Am Chem Soc. 2015 Jul 22;137(28):8983-90. doi: 10.1021/jacs.5b01442. Epub 2015 Jul 8. J Am Chem Soc. 2015. PMID: 26098608 Free PMC article.

3

Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery.

Reeve SM, Lombardo MN, Anderson AC. Reeve SM, et al. Future Microbiol. 2015;10(11):1727-33. doi: 10.2217/fmb.15.78. Epub 2015 Oct 30. Future Microbiol. 2015. PMID: 26516790 Free PMC article. Review.

4

Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.

Reeve SM, Scocchera E, Ferreira JJ, G-Dayanandan N, Keshipeddy S, Wright DL, Anderson AC. Reeve SM, et al. J Med Chem. 2016 Jul 14;59(13):6493-500. doi: 10.1021/acs.jmedchem.6b00688. Epub 2016 Jun 28. J Med Chem. 2016. PMID: 27308944 Free PMC article.

5

Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.

Scocchera E, Reeve SM, Keshipeddy S, Lombardo MN, Hajian B, Sochia AE, Alverson JB, Priestley ND, Anderson AC, Wright DL. Scocchera E, et al. Among authors: reeve sm. ACS Med Chem Lett. 2016 May 5;7(7):692-6. doi: 10.1021/acsmedchemlett.6b00120. eCollection 2016 Jul 14. ACS Med Chem Lett. 2016. PMID: 27437079 Free PMC article.

6

Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.

Hajian B, Scocchera E, Keshipeddy S, G-Dayanandan N, Shoen C, Krucinska J, Reeve S, Cynamon M, Anderson AC, Wright DL. Hajian B, et al. PLoS One. 2016 Aug 31;11(8):e0161740. doi: 10.1371/journal.pone.0161740. eCollection 2016. PLoS One. 2016. PMID: 27580226 Free PMC article.

7

OSPREY Predicts Resistance Mutations Using Positive and Negative Computational Protein Design.

Ojewole A, Lowegard A, Gainza P, Reeve SM, Georgiev I, Anderson AC, Donald BR. Ojewole A, et al. Among authors: reeve sm. Methods Mol Biol. 2017;1529:291-306. doi: 10.1007/978-1-4939-6637-0_15. Methods Mol Biol. 2017. PMID: 27914058 Free PMC article.

8

MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.

Reeve SM, Scocchera EW, G-Dayanadan N, Keshipeddy S, Krucinska J, Hajian B, Ferreira J, Nailor M, Aeschlimann J, Wright DL, Anderson AC. Reeve SM, et al. Cell Chem Biol. 2016 Dec 22;23(12):1458-1467. doi: 10.1016/j.chembiol.2016.11.007. Epub 2016 Dec 8. Cell Chem Biol. 2016. PMID: 27939900 Free PMC article.

9

Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates.

Lombardo MN, G-Dayanandan N, Keshipeddy S, Zhou W, Si D, Reeve SM, Alverson J, Barney P, Walker L, Hoody J, Priestley ND, Obach RS, Wright DL. Lombardo MN, et al. Among authors: reeve sm. Drug Metab Dispos. 2019 Sep;47(9):995-1003. doi: 10.1124/dmd.119.086504. Epub 2019 Jun 14. Drug Metab Dispos. 2019. PMID: 31201212 Free PMC article.

10

Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus.

Reeve SM, Si D, Krucinska J, Yan Y, Viswanathan K, Wang S, Holt GT, Frenkel MS, Ojewole AA, Estrada A, Agabiti SS, Alverson JB, Gibson ND, Priestley ND, Wiemer AJ, Donald BR, Wright DL. Reeve SM, et al. ACS Infect Dis. 2019 Nov 8;5(11):1896-1906. doi: 10.1021/acsinfecdis.9b00222. Epub 2019 Oct 15. ACS Infect Dis. 2019. PMID: 31565920 Free PMC article.

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