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Epoxy-α-lapachone has in vitro and in vivo anti-leishmania (Leishmania) amazonensis effects and inhibits serine proteinase activity in this parasite.
Souza-Silva F, Bourguignon SC, Pereira BA, Côrtes LM, de Oliveira LF, Henriques-Pons A, Finkelstein LC, Ferreira VF, Carneiro PF, de Pinho RT, Caffarena ER, Alves CR. Souza-Silva F, et al. Among authors: de pinho rt. Antimicrob Agents Chemother. 2015 Apr;59(4):1910-8. doi: 10.1128/AAC.04742-14. Epub 2015 Jan 12. Antimicrob Agents Chemother. 2015. PMID: 25583728 Free PMC article.
Trypanosoma cruzi: insights into naphthoquinone effects on growth and proteinase activity.
Bourguignon SC, Cavalcanti DF, de Souza AM, Castro HC, Rodrigues CR, Albuquerque MG, Santos DO, da Silva GG, da Silva FC, Ferreira VF, de Pinho RT, Alves CR. Bourguignon SC, et al. Among authors: de pinho rt. Exp Parasitol. 2011 Jan;127(1):160-6. doi: 10.1016/j.exppara.2010.07.007. Epub 2010 Jul 18. Exp Parasitol. 2011. PMID: 20647011 Free article.
Immunity and immune modulation in Trypanosoma cruzi infection.
Cardillo F, de Pinho RT, Antas PR, Mengel J. Cardillo F, et al. Among authors: de pinho rt. Pathog Dis. 2015 Dec;73(9):ftv082. doi: 10.1093/femspd/ftv082. Epub 2015 Oct 4. Pathog Dis. 2015. PMID: 26438729 Free PMC article. Review.