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Page 1
Rab5 and rac team up in cell motility.
Zech T, Machesky L. Zech T, et al. Among authors: machesky l. Cell. 2008 Jul 11;134(1):18-20. doi: 10.1016/j.cell.2008.06.039. Cell. 2008. PMID: 18614005 Free article.
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL, Timpson P, Li A, Cammareri P, Ridgway RA, Morton JP, Doyle B, Hegarty S, Rafferty M, Murphy IG, McDermott EW, Sheahan K, Pedone K, Finn AJ, Groben PA, Thomas NE, Hao H, Carson C, Norman JC, Machesky LM, Gallagher WM, Jackson IJ, Van Kempen L, Beermann F, Der C, Larue L, Welch HC, Ozanne BW, Sansom OJ. Lindsay CR, et al. Among authors: machesky lm. Nat Commun. 2011 Nov 22;2:555. doi: 10.1038/ncomms1560. Nat Commun. 2011. PMID: 22109529 Free PMC article.
N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods.
Yu X, Zech T, McDonald L, Gonzalez EG, Li A, Macpherson I, Schwarz JP, Spence H, Futó K, Timpson P, Nixon C, Ma Y, Anton IM, Visegrády B, Insall RH, Oien K, Blyth K, Norman JC, Machesky LM. Yu X, et al. Among authors: machesky lm. J Cell Biol. 2012 Oct 29;199(3):527-44. doi: 10.1083/jcb.201203025. Epub 2012 Oct 22. J Cell Biol. 2012. PMID: 23091069 Free PMC article.
Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes.
Li A, Morton JP, Ma Y, Karim SA, Zhou Y, Faller WJ, Woodham EF, Morris HT, Stevenson RP, Juin A, Jamieson NB, MacKay CJ, Carter CR, Leung HY, Yamashiro S, Blyth K, Sansom OJ, Machesky LM. Li A, et al. Gastroenterology. 2014 May;146(5):1386-96.e1-17. doi: 10.1053/j.gastro.2014.01.046. Epub 2014 Jan 23. Gastroenterology. 2014. PMID: 24462734 Free PMC article.
Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.
Fort L, Batista JM, Thomason PA, Spence HJ, Whitelaw JA, Tweedy L, Greaves J, Martin KJ, Anderson KI, Brown P, Lilla S, Neilson MP, Tafelmeyer P, Zanivan S, Ismail S, Bryant DM, Tomkinson NCO, Chamberlain LH, Mastick GS, Insall RH, Machesky LM. Fort L, et al. Among authors: machesky lm. Nat Cell Biol. 2018 Oct;20(10):1159-1171. doi: 10.1038/s41556-018-0198-9. Epub 2018 Sep 24. Nat Cell Biol. 2018. PMID: 30250061 Free PMC article.
N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis.
Juin A, Spence HJ, Martin KJ, McGhee E, Neilson M, Cutiongco MFA, Gadegaard N, Mackay G, Fort L, Lilla S, Kalna G, Thomason P, Koh YWH, Norman JC, Insall RH, Machesky LM. Juin A, et al. Among authors: machesky lm. Dev Cell. 2019 Nov 18;51(4):431-445.e7. doi: 10.1016/j.devcel.2019.09.018. Epub 2019 Oct 24. Dev Cell. 2019. PMID: 31668663 Free PMC article.
216 results