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Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain structures.
Monn JA, Prieto L, Taboada L, Pedregal C, Hao J, Reinhard MR, Henry SS, Goldsmith PJ, Beadle CD, Walton L, Man T, Rudyk H, Clark B, Tupper D, Baker SR, Lamas C, Montero C, Marcos A, Blanco J, Bures M, Clawson DK, Atwell S, Lu F, Wang J, Russell M, Heinz BA, Wang X, Carter JH, Xiang C, Catlow JT, Swanson S, Sanger H, Broad LM, Johnson MP, Knopp KL, Simmons RM, Johnson BG, Shaw DB, McKinzie DL. Monn JA, et al. Among authors: blanco j. J Med Chem. 2015 Feb 26;58(4):1776-94. doi: 10.1021/jm501612y. Epub 2015 Feb 5. J Med Chem. 2015. PMID: 25602126
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
Monn JA, Prieto L, Taboada L, Hao J, Reinhard MR, Henry SS, Beadle CD, Walton L, Man T, Rudyk H, Clark B, Tupper D, Baker SR, Lamas C, Montero C, Marcos A, Blanco J, Bures M, Clawson DK, Atwell S, Lu F, Wang J, Russell M, Heinz BA, Wang X, Carter JH, Getman BG, Catlow JT, Swanson S, Johnson BG, Shaw DB, McKinzie DL. Monn JA, et al. Among authors: blanco j. J Med Chem. 2015 Sep 24;58(18):7526-48. doi: 10.1021/acs.jmedchem.5b01124. J Med Chem. 2015. PMID: 26313429
Initial antigen encounter determines robust T-cell immunity against SARS-CoV-2 BA.2.86 variant three years later.
Rubio R, Yavlinsky A, Zamudio ME, Molinos-Albert LM, Pérez CM, Pradenas E, Canyelles M, Torres C, Tan C, Swadling L, Ramírez-Morros A, Trinité B, Vidal-Alaball J, Aguilar R, Ruiz-Comellas A, Blanco J, van Dorp L, Balloux F, Dobaño C, Moncunill G. Rubio R, et al. Among authors: blanco j. J Infect. 2024 Dec 31:106402. doi: 10.1016/j.jinf.2024.106402. Online ahead of print. J Infect. 2024. PMID: 39746406
Long-term effectiveness and tolerability of dolutegravir/lamivudine in treatment-naive people with HIV: an analysis of a multicentre cohort at 96 weeks.
Suárez-García I, Alejos B, Moreno C, Martín Torres J, Masiá M, García-Fraile LJ, Riera M, Dalmau D, Rodríguez-Rosado R, Muga R, Moreno S, Jarrín I; CoRIS cohort. Suárez-García I, et al. J Antimicrob Chemother. 2024 Dec 23:dkae456. doi: 10.1093/jac/dkae456. Online ahead of print. J Antimicrob Chemother. 2024. PMID: 39710424
MEG8 as an antagonistic pleiotropic mechanism in breast cancer.
Verdugo-Sivianes EM, Espinosa-Sánchez A, Cases I, Rojas AM, Otero-Albiol D, Romero L, Blanco JR, Carnero A. Verdugo-Sivianes EM, et al. Among authors: blanco jr. Cell Death Discov. 2024 Dec 20;10(1):509. doi: 10.1038/s41420-024-02272-0. Cell Death Discov. 2024. PMID: 39706842 Free PMC article.
A Contemporary Picture of Coagulase-Negative Staphylococcal Endocarditis: A Nationwide GAMES Cohort Study.
Palom-Grau C, Cuervo G, Muñoz P, Marín Arriaza M, Martínez-Sellés M, González-Ramallo V, de Alarcón A, Poyato-Borrego M, Rodríguez-García R, Rodríguez-Esteban MÁ, Fariñas MC, González-Rico C, Goenaga MÁ, Ojeda-Burgos G, Goikoetxea-Agirre AJ, Calderón-Parra J, López-Azor JC, García-Vázquez E, Loeches B, Quintana E, García de la Mària C, Llopis J, Miró JM; GAMES Investigators. Palom-Grau C, et al. J Am Coll Cardiol. 2024 Oct 25:S0735-1097(24)08573-5. doi: 10.1016/j.jacc.2024.09.027. Online ahead of print. J Am Coll Cardiol. 2024. PMID: 39580721
Loneliness and social isolation in people with HIV aged ≥50 years. The No One Alone (NOA)-GeSIDA study conducted by the GeSIDA 12021 study group.
Blanco JR, Gonzalez-Baeza A, Martinez-Vicente A, Albendin-Iglesias H, De La Torre J, Jarrin I, González-Cuello I, Cabello-Clotet N, Barrios-Blandino AM, Sanjoaquin-Conde I, Montes-Ramirez ML, Melus E, Pérez-Esquerdo V, Tomas-Jimenez C, Saumoy-Linares M, Lopez-Lirola AM, Hidalgo-Tenorio C, Muelas-Fernandez M, Galindo-Puerto MJ, Abadía J, Manzanares E, Segundo-Martin C, Fernandez-Lopez MA, Barrios-Vega M, De Miguel M, Olalla J; Grupo_Estudio_Gesida_12021. Blanco JR, et al. HIV Med. 2024 Nov 22. doi: 10.1111/hiv.13743. Online ahead of print. HIV Med. 2024. PMID: 39578382
2,695 results