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Malaria induces anemia through CD8+ T cell-dependent parasite clearance and erythrocyte removal in the spleen.
Safeukui I, Gomez ND, Adelani AA, Burte F, Afolabi NK, Akondy R, Velazquez P, Holder A, Tewari R, Buffet P, Brown BJ, Shokunbi WA, Olaleye D, Sodeinde O, Kazura J, Ahmed R, Mohandas N, Fernandez-Reyes D, Haldar K. Safeukui I, et al. Among authors: adelani aa. mBio. 2015 Jan 20;6(1):e02493-14. doi: 10.1128/mBio.02493-14. mBio. 2015. PMID: 25604792 Free PMC article.
Deletion of a malaria invasion gene reduces death and anemia, in model hosts.
Gómez ND, Safeukui I, Adelani AA, Tewari R, Reddy JK, Rao S, Holder A, Buffet P, Mohandas N, Haldar K. Gómez ND, et al. Among authors: adelani aa. PLoS One. 2011;6(9):e25477. doi: 10.1371/journal.pone.0025477. Epub 2011 Sep 28. PLoS One. 2011. PMID: 21980474 Free PMC article.