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The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB, Ayata C, Maxwell MM, Steegborn C, Schwarzschild MA, Outeiro TF, Kazantsev AG. Chen X, et al. Among authors: zuo f. PLoS One. 2015 Jan 21;10(1):e0116919. doi: 10.1371/journal.pone.0116919. eCollection 2015. PLoS One. 2015. PMID: 25608039 Free PMC article.
The melanoma-linked "redhead" MC1R influences dopaminergic neuron survival.
Chen X, Chen H, Cai W, Maguire M, Ya B, Zuo F, Logan R, Li H, Robinson K, Vanderburg CR, Yu Y, Wang Y, Fisher DE, Schwarzschild MA. Chen X, et al. Among authors: zuo f. Ann Neurol. 2017 Mar;81(3):395-406. doi: 10.1002/ana.24852. Epub 2017 Jan 23. Ann Neurol. 2017. PMID: 28019657 Free PMC article.
Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease.
Chen X, Umeh CC, Tainsh RE, Feng DD, Maguire M, Zuo F, Rahimian M, Logan R, Wang X, Ascherio A, Macklin EA, Buys ES, Schwarzschild MA; Parkinson Study Group (PSG) The Safety of Urate Elevation in Parkinson's Disease (SURE-PD) investigators. Chen X, et al. Among authors: zuo f. EBioMedicine. 2018 Nov;37:259-268. doi: 10.1016/j.ebiom.2018.10.039. Epub 2018 Nov 8. EBioMedicine. 2018. PMID: 30415890 Free PMC article. Clinical Trial.
499 results