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Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ-dependent and PPARγ-independent actions.
Belchior T, Paschoal VA, Magdalon J, Chimin P, Farias TM, Chaves-Filho AB, Gorjão R, St-Pierre P, Miyamoto S, Kang JX, Deshaies Y, Marette A, Festuccia W. Belchior T, et al. Mol Nutr Food Res. 2015 May;59(5):957-67. doi: 10.1002/mnfr.201400914. Epub 2015 Mar 16. Mol Nutr Food Res. 2015. PMID: 25641959
Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.
Chimin P, Andrade ML, Belchior T, Paschoal VA, Magdalon J, Yamashita AS, Castro É, Castoldi A, Chaves-Filho AB, Yoshinaga MY, Miyamoto S, Câmara NO, Festuccia WT. Chimin P, et al. J Lipid Res. 2017 Sep;58(9):1797-1807. doi: 10.1194/jlr.M074518. Epub 2017 Jul 5. J Lipid Res. 2017. PMID: 28679588 Free PMC article.
Fish Oil Protects Wild Type and Uncoupling Protein 1-Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure.
Oliveira TE, Castro É, Belchior T, Andrade ML, Chaves-Filho AB, Peixoto AS, Moreno MF, Ortiz-Silva M, Moreira RJ, Inague A, Yoshinaga MY, Miyamoto S, Moustaid-Moussa N, Festuccia WT. Oliveira TE, et al. Mol Nutr Food Res. 2019 Apr;63(7):e1800813. doi: 10.1002/mnfr.201800813. Epub 2019 Jan 17. Mol Nutr Food Res. 2019. PMID: 30632684
Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids.
Moreira RJ, Castro É, Oliveira TE, Belchior T, Peixoto AS, Chaves-Filho AB, Moreno MF, Lima JD, Yoshinaga M, Miyamoto S, Morais MRPT, Zorn TMT, Cogliati B, Iwai LK, Palmisano G, Cabral FJ, Festuccia W. Moreira RJ, et al. Mol Nutr Food Res. 2020 Apr;64(7):e1900833. doi: 10.1002/mnfr.201900833. Epub 2020 Feb 3. Mol Nutr Food Res. 2020. PMID: 31978277
Palmitoleic acid reduces high fat diet-induced liver inflammation by promoting PPAR-γ-independent M2a polarization of myeloid cells.
Souza CO, Teixeira AAS, Biondo LA, Silveira LS, de Souza Breda CN, Braga TT, Camara NOS, Belchior T, Festuccia WT, Diniz TA, Ferreira GM, Hirata MH, Chaves-Filho AB, Yoshinaga MY, Miyamoto S, Calder PC, Sethi JK, Rosa Neto JC. Souza CO, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Oct;1865(10):158776. doi: 10.1016/j.bbalip.2020.158776. Epub 2020 Jul 30. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32738301 Free PMC article.
PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity.
Andrade ML, Gilio GR, Perandini LA, Peixoto AS, Moreno MF, Castro É, Oliveira TE, Vieira TS, Ortiz-Silva M, Thomazelli CA, Chaves-Filho AB, Belchior T, Chimin P, Magdalon J, Ivison R, Pant D, Tsai L, Yoshinaga MY, Miyamoto S, Festuccia WT. Andrade ML, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158967. doi: 10.1016/j.bbalip.2021.158967. Epub 2021 May 15. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 34004356 Free PMC article.
32 results