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DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling.
Northcutt AL, Hutchinson MR, Wang X, Baratta MV, Hiranita T, Cochran TA, Pomrenze MB, Galer EL, Kopajtic TA, Li CM, Amat J, Larson G, Cooper DC, Huang Y, O'Neill CE, Yin H, Zahniser NR, Katz JL, Rice KC, Maier SF, Bachtell RK, Watkins LR. Northcutt AL, et al. Among authors: rice kc. Mol Psychiatry. 2015 Dec;20(12):1525-37. doi: 10.1038/mp.2014.177. Epub 2015 Feb 3. Mol Psychiatry. 2015. PMID: 25644383 Free PMC article.
Evidence that opioids may have toll-like receptor 4 and MD-2 effects.
Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, Falke JJ, Leinwand LA, Maier SF, Yin H, Rice KC, Watkins LR. Hutchinson MR, et al. Among authors: rice kc. Brain Behav Immun. 2010 Jan;24(1):83-95. doi: 10.1016/j.bbi.2009.08.004. Epub 2009 Aug 11. Brain Behav Immun. 2010. PMID: 19679181 Free PMC article.
Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.
Hutchinson MR, Lewis SS, Coats BD, Rezvani N, Zhang Y, Wieseler JL, Somogyi AA, Yin H, Maier SF, Rice KC, Watkins LR. Hutchinson MR, et al. Among authors: rice kc. Neuroscience. 2010 May 19;167(3):880-93. doi: 10.1016/j.neuroscience.2010.02.011. Epub 2010 Feb 21. Neuroscience. 2010. PMID: 20178837 Free PMC article.
872 results