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Pharmacophore identification of c-Myc inhibitor 10074-G5.
Yap JL, Wang H, Hu A, Chauhan J, Jung KY, Gharavi RB, Prochownik EV, Fletcher S. Yap JL, et al. Among authors: fletcher s. Bioorg Med Chem Lett. 2013 Jan 1;23(1):370-4. doi: 10.1016/j.bmcl.2012.10.013. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2013. PMID: 23177256 Free PMC article.
Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling.
Jung KY, Samadani R, Chauhan J, Nevels K, Yap JL, Zhang J, Worlikar S, Lanning ME, Chen L, Ensey M, Shukla S, Salmo R, Heinzl G, Gordon C, Dukes T, MacKerell AD Jr, Shapiro P, Fletcher S. Jung KY, et al. Among authors: fletcher s. Org Biomol Chem. 2013 Jun 14;11(22):3706-32. doi: 10.1039/c3ob40199e. Org Biomol Chem. 2013. PMID: 23624850 Free PMC article.
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak.
Cao X, Yap JL, Newell-Rogers MK, Peddaboina C, Jiang W, Papaconstantinou HT, Jupitor D, Rai A, Jung KY, Tubin RP, Yu W, Vanommeslaeghe K, Wilder PT, MacKerell AD Jr, Fletcher S, Smythe RW. Cao X, et al. Among authors: fletcher s. Mol Cancer. 2013 May 16;12(1):42. doi: 10.1186/1476-4598-12-42. Mol Cancer. 2013. PMID: 23680104 Free PMC article.
Small-molecule inhibitors of the Myc oncoprotein.
Fletcher S, Prochownik EV. Fletcher S, et al. Biochim Biophys Acta. 2015 May;1849(5):525-43. doi: 10.1016/j.bbagrm.2014.03.005. Epub 2014 Mar 19. Biochim Biophys Acta. 2015. PMID: 24657798 Free PMC article. Review.
1,526 results