Shapiro P - Search Results

1

Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf.

Samadani R, Zhang J, Brophy A, Oashi T, Priyakumar UD, Raman EP, St John FJ, Jung KY, Fletcher S, Pozharski E, MacKerell AD Jr, Shapiro P. Samadani R, et al. Among authors: shapiro p. Biochem J. 2015 May 1;467(3):425-38. doi: 10.1042/BJ20131571. Biochem J. 2015. PMID: 25695333 Free PMC article.

2

Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.

Shapiro P. Shapiro P. Crit Rev Clin Lab Sci. 2002 Sep;39(4-5):285-330. doi: 10.1080/10408360290795538. Crit Rev Clin Lab Sci. 2002. PMID: 12385501 Review.

3

Phosphorylation regulates nucleophosmin targeting to the centrosome during mitosis as detected by cross-reactive phosphorylation-specific MKK1/MKK2 antibodies.

Cha H, Hancock C, Dangi S, Maiguel D, Carrier F, Shapiro P. Cha H, et al. Among authors: shapiro p. Biochem J. 2004 Mar 15;378(Pt 3):857-65. doi: 10.1042/BJ20031173. Biochem J. 2004. PMID: 14670079 Free PMC article.

4

Cdc2-mediated inhibition of epidermal growth factor activation of the extracellular signal-regulated kinase pathway during mitosis.

Dangi S, Shapiro P. Dangi S, et al. Among authors: shapiro p. J Biol Chem. 2005 Jul 1;280(26):24524-31. doi: 10.1074/jbc.M414079200. Epub 2005 May 11. J Biol Chem. 2005. PMID: 15888452 Free article.

5

Identification of novel extracellular signal-regulated kinase docking domain inhibitors.

Hancock CN, Macias A, Lee EK, Yu SY, Mackerell AD Jr, Shapiro P. Hancock CN, et al. Among authors: shapiro p. J Med Chem. 2005 Jul 14;48(14):4586-95. doi: 10.1021/jm0501174. J Med Chem. 2005. PMID: 15999996

6

Neuronal nitric oxide synthase-induced S-nitrosylation of H-Ras inhibits calcium ionophore-mediated extracellular-signal-regulated kinase activity.

Raines KW, Cao GL, Lee EK, Rosen GM, Shapiro P. Raines KW, et al. Among authors: shapiro p. Biochem J. 2006 Jul 15;397(2):329-36. doi: 10.1042/BJ20052002. Biochem J. 2006. PMID: 16569214 Free PMC article.

7

Mitogen activated protein (MAP) kinases: development of ATP and non-ATP dependent inhibitors.

Hancock CN, Macias AT, Mackerell AD Jr, Shapiro P. Hancock CN, et al. Among authors: shapiro p. Med Chem. 2006 Mar;2(2):213-22. doi: 10.2174/157340606776056151. Med Chem. 2006. PMID: 16787369 Review.

8

Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure.

Chen F, Hancock CN, Macias AT, Joh J, Still K, Zhong S, MacKerell AD Jr, Shapiro P. Chen F, et al. Among authors: shapiro p. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6281-7. doi: 10.1016/j.bmcl.2006.09.038. Epub 2006 Sep 26. Bioorg Med Chem Lett. 2006. PMID: 17000106 Free PMC article.

9

Using Caenorhabditis elegans as a model organism for evaluating extracellular signal-regulated kinase docking domain inhibitors.

Chen F, Mackerell AD Jr, Luo Y, Shapiro P. Chen F, et al. Among authors: shapiro p. J Cell Commun Signal. 2008 Dec;2(3-4):81-92. doi: 10.1007/s12079-008-0034-2. Epub 2008 Dec 23. J Cell Commun Signal. 2008. PMID: 19105050 Free PMC article.

10

Development of extracellular signal-regulated kinase inhibitors.

Burkhard K, Smith S, Deshmukh R, MacKerell AD Jr, Shapiro P. Burkhard K, et al. Among authors: shapiro p. Curr Top Med Chem. 2009;9(8):678-89. doi: 10.2174/156802609789044416. Curr Top Med Chem. 2009. PMID: 19689374 Free PMC article. Review.

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