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Oxidation increases mucin polymer cross-links to stiffen airway mucus gels.
Yuan S, Hollinger M, Lachowicz-Scroggins ME, Kerr SC, Dunican EM, Daniel BM, Ghosh S, Erzurum SC, Willard B, Hazen SL, Huang X, Carrington SD, Oscarson S, Fahy JV. Yuan S, et al. Among authors: huang x. Sci Transl Med. 2015 Feb 25;7(276):276ra27. doi: 10.1126/scitranslmed.3010525. Sci Transl Med. 2015. PMID: 25717100 Free PMC article.
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ. Park SW, et al. Among authors: huang x. Am J Respir Crit Care Med. 2009 Oct 1;180(7):603-10. doi: 10.1164/rccm.200811-1768OC. Epub 2009 Jul 23. Am J Respir Crit Care Med. 2009. PMID: 19628779 Free PMC article.
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Huang F, et al. Among authors: huang x. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16354-9. doi: 10.1073/pnas.1214596109. Epub 2012 Sep 17. Proc Natl Acad Sci U S A. 2012. PMID: 22988107 Free PMC article.
A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production.
Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM. Simpson LJ, et al. Among authors: huang x. Nat Immunol. 2014 Dec;15(12):1162-70. doi: 10.1038/ni.3026. Epub 2014 Nov 2. Nat Immunol. 2014. PMID: 25362490 Free PMC article.
AGR2 is induced in asthma and promotes allergen-induced mucin overproduction.
Schroeder BW, Verhaeghe C, Park SW, Nguyenvu LT, Huang X, Zhen G, Erle DJ. Schroeder BW, et al. Among authors: huang x. Am J Respir Cell Mol Biol. 2012 Aug;47(2):178-85. doi: 10.1165/rcmb.2011-0421OC. Epub 2012 Mar 8. Am J Respir Cell Mol Biol. 2012. PMID: 22403803 Free PMC article.
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