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N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model.
Hoveyda HR, Fraser GL, Zoute L, Dutheuil G, Schils D, Brantis C, Lapin A, Parcq J, Guitard S, Lenoir F, Bousmaqui ME, Rorive S, Hospied S, Blanc S, Bernard J, Ooms F, McNelis JC, Olefsky JM. Hoveyda HR, et al. Among authors: blanc s. Bioorg Med Chem. 2018 Oct 1;26(18):5169-5180. doi: 10.1016/j.bmc.2018.09.015. Epub 2018 Sep 18. Bioorg Med Chem. 2018. PMID: 30253886
Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.
Dolušić E, Larrieu P, Blanc S, Sapunaric F, Pouyez J, Moineaux L, Colette D, Stroobant V, Pilotte L, Colau D, Ferain T, Fraser G, Galleni M, Frère JM, Masereel B, Van den Eynde B, Wouters J, Frédérick R. Dolušić E, et al. Among authors: blanc s. Eur J Med Chem. 2011 Jul;46(7):3058-65. doi: 10.1016/j.ejmech.2011.02.049. Epub 2011 Feb 26. Eur J Med Chem. 2011. PMID: 21419531 Free article.
Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.
Dolušić E, Larrieu P, Blanc S, Sapunaric F, Norberg B, Moineaux L, Colette D, Stroobant V, Pilotte L, Colau D, Ferain T, Fraser G, Galleni M, Frère JM, Masereel B, Van den Eynde B, Wouters J, Frédérick R. Dolušić E, et al. Among authors: blanc s. Bioorg Med Chem. 2011 Feb 15;19(4):1550-61. doi: 10.1016/j.bmc.2010.12.032. Epub 2010 Dec 16. Bioorg Med Chem. 2011. PMID: 21269836 Free article.
Biological diversity from a structurally diverse library: systematically scanning conformational space using a pyranose scaffold.
Abbenante G, Becker B, Blanc S, Clark C, Condie G, Fraser G, Grathwohl M, Halliday J, Henderson S, Lam A, Liu L, Mann M, Muldoon C, Pearson A, Premraj R, Ramsdale T, Rossetti T, Schafer K, Le Thanh G, Tometzki G, Vari F, Verquin G, Waanders J, West M, Wimmer N, Yau A, Zuegg J, Meutermans W. Abbenante G, et al. Among authors: blanc s. J Med Chem. 2010 Aug 12;53(15):5576-86. doi: 10.1021/jm1002777. J Med Chem. 2010. PMID: 20684600
405 results