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Page 1
Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBPβ.
Falkenberg KD, Jakobs A, Matern JC, Dörner W, Uttarkar S, Trentmann A, Steinmann S, Coulibaly A, Schomburg C, Mootz HD, Schmidt TJ, Klempnauer KH. Falkenberg KD, et al. Among authors: uttarkar s. Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1349-1358. doi: 10.1016/j.bbamcr.2017.05.003. Epub 2017 May 2. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28476645 Free article.
An isoform-specific C/EBPβ inhibitor targets acute myeloid leukemia cells.
Jakobs A, Uttarkar S, Schomburg C, Steinmann S, Coulibaly A, Schlenke P, Berdel WE, Müller-Tidow C, Schmidt TJ, Klempnauer KH. Jakobs A, et al. Among authors: uttarkar s. Leukemia. 2016 Jul;30(7):1612-5. doi: 10.1038/leu.2016.16. Epub 2016 Feb 8. Leukemia. 2016. PMID: 26854027 No abstract available.
3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.
Hewings DS, Wang M, Philpott M, Fedorov O, Uttarkar S, Filippakopoulos P, Picaud S, Vuppusetty C, Marsden B, Knapp S, Conway SJ, Heightman TD. Hewings DS, et al. Among authors: uttarkar s. J Med Chem. 2011 Oct 13;54(19):6761-70. doi: 10.1021/jm200640v. Epub 2011 Sep 6. J Med Chem. 2011. PMID: 21851057 Free PMC article.