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Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance.
Ramon-Krauel M, Pentinat T, Bloks VW, Cebrià J, Ribo S, Pérez-Wienese R, Vilà M, Palacios-Marin I, Fernández-Pérez A, Vallejo M, Téllez N, Rodríguez MÀ, Yanes O, Lerin C, Díaz R, Plosch T, Tietge UJF, Jimenez-Chillaron JC. Ramon-Krauel M, et al. FASEB J. 2018 May 29:fj201700717RR. doi: 10.1096/fj.201700717RR. Online ahead of print. FASEB J. 2018. PMID: 29812971
H3K9me3 demethylation by JMJD2B is regulated by pirfenidone resulting in improved NASH.
Rodriguez-Sanabria JS, Rosas-Campos R, Vázquez-Esqueda Á, Palacios-Marín I, Jiménez-Chillaron J, Escutia-Gutiérrez R, Jave-Suarez LF, Galicia-Moreno M, Monroy-Ramirez HC, Cerda-Reyes E, Almeida-López M, Martinez-Lopez E, Herrera LA, Armendáriz-Borunda J, Sandoval-Rodriguez A. Rodriguez-Sanabria JS, et al. Sci Rep. 2024 Oct 21;14(1):24714. doi: 10.1038/s41598-024-75458-2. Sci Rep. 2024. PMID: 39433954 Free PMC article.
In utero undernutrition in male mice programs liver lipid metabolism in the second-generation offspring involving altered Lxra DNA methylation.
Martínez D, Pentinat T, Ribó S, Daviaud C, Bloks VW, Cebrià J, Villalmanzo N, Kalko SG, Ramón-Krauel M, Díaz R, Plösch T, Tost J, Jiménez-Chillarón JC. Martínez D, et al. Cell Metab. 2014 Jun 3;19(6):941-51. doi: 10.1016/j.cmet.2014.03.026. Epub 2014 May 1. Cell Metab. 2014. PMID: 24794974 Free article.
Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD.
Ribas-Aulinas F, Ribo S, Parra-Vargas M, Fernández-Pérez A, Cebrià J, Guardiola-Perello M, Ramon-Krauel M, Lerin C, Diaz R, Kalko SG, Vallejo M, Díez-Noguera A, Cambras T, Jimenez-Chillaron JC. Ribas-Aulinas F, et al. Among authors: jimenez chillaron jc. Mol Metab. 2021 Mar;45:101162. doi: 10.1016/j.molmet.2021.101162. Epub 2021 Jan 7. Mol Metab. 2021. PMID: 33422644 Free PMC article.
38 results