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A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production.
Nachbur U, Stafford CA, Bankovacki A, Zhan Y, Lindqvist LM, Fiil BK, Khakham Y, Ko HJ, Sandow JJ, Falk H, Holien JK, Chau D, Hildebrand J, Vince JE, Sharp PP, Webb AI, Jackman KA, Mühlen S, Kennedy CL, Lowes KN, Murphy JM, Gyrd-Hansen M, Parker MW, Hartland EL, Lew AM, Huang DC, Lessene G, Silke J. Nachbur U, et al. Among authors: stafford ca. Nat Commun. 2015 Mar 17;6:6442. doi: 10.1038/ncomms7442. Nat Commun. 2015. PMID: 25778803 Free article.
A NODding acquaintance with ER stress.
Stafford CA, Nachbur U. Stafford CA, et al. Cell Death Discov. 2016 May 30;2:16037. doi: 10.1038/cddiscovery.2016.37. eCollection 2016. Cell Death Discov. 2016. PMID: 27551527 Free PMC article. No abstract available.
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy.
Bernardini JP, Brouwer JM, Tan IK, Sandow JJ, Huang S, Stafford CA, Bankovacki A, Riffkin CD, Wardak AZ, Czabotar PE, Lazarou M, Dewson G. Bernardini JP, et al. Among authors: stafford ca. EMBO J. 2019 Jan 15;38(2):e99916. doi: 10.15252/embj.201899916. Epub 2018 Dec 20. EMBO J. 2019. PMID: 30573668 Free PMC article.
NOD Signaling and Cell Death.
Heim VJ, Stafford CA, Nachbur U. Heim VJ, et al. Among authors: stafford ca. Front Cell Dev Biol. 2019 Oct 2;7:208. doi: 10.3389/fcell.2019.00208. eCollection 2019. Front Cell Dev Biol. 2019. PMID: 31632962 Free PMC article. Review.
Oligomerization-driven MLKL ubiquitylation antagonizes necroptosis.
Liu Z, Dagley LF, Shield-Artin K, Young SN, Bankovacki A, Wang X, Tang M, Howitt J, Stafford CA, Nachbur U, Fitzgibbon C, Garnish SE, Webb AI, Komander D, Murphy JM, Hildebrand JM, Silke J. Liu Z, et al. Among authors: stafford ca. EMBO J. 2021 Dec 1;40(23):e103718. doi: 10.15252/embj.2019103718. Epub 2021 Oct 26. EMBO J. 2021. PMID: 34698396 Free PMC article.
Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
Stafford CA, Gassauer AM, de Oliveira Mann CC, Tanzer MC, Fessler E, Wefers B, Nagl D, Kuut G, Sulek K, Vasilopoulou C, Schwojer SJ, Wiest A, Pfautsch MK, Wurst W, Yabal M, Fröhlich T, Mann M, Gisch N, Jae LT, Hornung V. Stafford CA, et al. Nature. 2022 Sep;609(7927):590-596. doi: 10.1038/s41586-022-05125-x. Epub 2022 Aug 24. Nature. 2022. PMID: 36002575 Free PMC article.
70 results