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Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder.
Lanz TA, Reinhart V, Sheehan MJ, Rizzo SJS, Bove SE, James LC, Volfson D, Lewis DA, Kleiman RJ. Lanz TA, et al. Among authors: kleiman rj. Transl Psychiatry. 2019 May 23;9(1):151. doi: 10.1038/s41398-019-0492-8. Transl Psychiatry. 2019. PMID: 31123247 Free PMC article.
Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma.
Lanz TA, Bove SE, Pilsmaker CD, Mariga A, Drummond EM, Cadelina GW, Adamowicz WO, Swetter BJ, Carmel S, Dumin JA, Kleiman RJ. Lanz TA, et al. Among authors: kleiman rj. Biomarkers. 2012 Sep;17(6):524-31. doi: 10.3109/1354750X.2012.694476. Epub 2012 Jun 7. Biomarkers. 2012. PMID: 22672085
Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease.
Kleiman RJ, Kimmel LH, Bove SE, Lanz TA, Harms JF, Romegialli A, Miller KS, Willis A, des Etages S, Kuhn M, Schmidt CJ. Kleiman RJ, et al. J Pharmacol Exp Ther. 2011 Jan;336(1):64-76. doi: 10.1124/jpet.110.173294. Epub 2010 Oct 5. J Pharmacol Exp Ther. 2011. PMID: 20923867
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.
Miller BH, Zeier Z, Xi L, Lanz TA, Deng S, Strathmann J, Willoughby D, Kenny PJ, Elsworth JD, Lawrence MS, Roth RH, Edbauer D, Kleiman RJ, Wahlestedt C. Miller BH, et al. Among authors: kleiman rj. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3125-30. doi: 10.1073/pnas.1113793109. Epub 2012 Feb 6. Proc Natl Acad Sci U S A. 2012. PMID: 22315408 Free PMC article.
A survey of rare coding variants in candidate genes in schizophrenia by deep sequencing.
Hu X, Zhang B, Liu W, Paciga S, He W, Lanz TA, Kleiman R, Dougherty B, Hall SK, McIntosh AM, Lawrie SM, Power A, John SL, Blackwood D, St Clair D, Brandon NJ. Hu X, et al. Mol Psychiatry. 2014 Aug;19(8):857-8. doi: 10.1038/mp.2013.131. Epub 2013 Oct 15. Mol Psychiatry. 2014. PMID: 24126932 Free PMC article. No abstract available.
Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports.
Brownstein CA, Kleiman RJ, Engle EC, Towne MC, D'Angelo EJ, Yu TW, Beggs AH, Picker J, Fogler JM, Carroll D, Schmitt RC, Wolff RR, Shen Y, Lip V, Bilguvar K, Kim A, Tembulkar S, O'Donnell K, Gonzalez-Heydrich J. Brownstein CA, et al. Among authors: kleiman rj. Am J Med Genet A. 2016 May;170A(5):1165-73. doi: 10.1002/ajmg.a.37595. Epub 2016 Feb 16. Am J Med Genet A. 2016. PMID: 26887912 Free PMC article.
48 results