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Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.
Schonauer S, Körschen HG, Penno A, Rennhack A, Breiden B, Sandhoff K, Gutbrod K, Dörmann P, Raju DN, Haberkant P, Gerl MJ, Brügger B, Zigdon H, Vardi A, Futerman AH, Thiele C, Wachten D. Schonauer S, et al. Among authors: wachten d. J Biol Chem. 2017 Apr 14;292(15):6177-6189. doi: 10.1074/jbc.M116.762831. Epub 2017 Mar 3. J Biol Chem. 2017. PMID: 28258214 Free PMC article.
Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations.
Woeste MA, Stern S, Raju DN, Grahn E, Dittmann D, Gutbrod K, Dörmann P, Hansen JN, Schonauer S, Marx CE, Hamzeh H, Körschen HG, Aerts JMFG, Bönigk W, Endepols H, Sandhoff R, Geyer M, Berger TK, Bradke F, Wachten D. Woeste MA, et al. Among authors: wachten d. J Biol Chem. 2019 Mar 15;294(11):3853-3871. doi: 10.1074/jbc.RA118.006311. Epub 2019 Jan 20. J Biol Chem. 2019. PMID: 30662006 Free PMC article.
A novel biosensor to study cAMP dynamics in cilia and flagella.
Mukherjee S, Jansen V, Jikeli JF, Hamzeh H, Alvarez L, Dombrowski M, Balbach M, Strünker T, Seifert R, Kaupp UB, Wachten D. Mukherjee S, et al. Among authors: wachten d. Elife. 2016 Mar 22;5:e14052. doi: 10.7554/eLife.14052. Elife. 2016. PMID: 27003291 Free PMC article.
Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm.
Balbach M, Hamzeh H, Jikeli JF, Brenker C, Schiffer C, Hansen JN, Neugebauer P, Trötschel C, Jovine L, Han L, Florman HM, Kaupp UB, Strünker T, Wachten D. Balbach M, et al. Among authors: wachten d. Front Cell Dev Biol. 2020 Aug 31;8:572735. doi: 10.3389/fcell.2020.572735. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32984353 Free PMC article.
Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling.
Schiffer C, Rieger S, Brenker C, Young S, Hamzeh H, Wachten D, Tüttelmann F, Röpke A, Kaupp UB, Wang T, Wagner A, Krallmann C, Kliesch S, Fallnich C, Strünker T. Schiffer C, et al. Among authors: wachten d. EMBO J. 2020 Feb 17;39(4):e102363. doi: 10.15252/embj.2019102363. Epub 2020 Jan 19. EMBO J. 2020. PMID: 31957048 Free PMC article.
1-O-acylceramides are natural components of human and mouse epidermis.
Rabionet M, Bayerle A, Marsching C, Jennemann R, Gröne HJ, Yildiz Y, Wachten D, Shaw W, Shayman JA, Sandhoff R. Rabionet M, et al. Among authors: wachten d. J Lipid Res. 2013 Dec;54(12):3312-21. doi: 10.1194/jlr.M040097. Epub 2013 Sep 27. J Lipid Res. 2013. PMID: 24078707 Free PMC article.
63 results