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Page 1
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs.
Manetti D, Martini E, Ghelardini C, Dei S, Galeotti N, Guandalini L, Romanelli MN, Scapecchi S, Teodori E, Bartolini A, Gualtieri F. Manetti D, et al. Among authors: guandalini l. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2303-6. doi: 10.1016/s0960-894x(03)00437-2. Bioorg Med Chem Lett. 2003. PMID: 12824022
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.
Scapecchi S, Matucci R, Bellucci C, Buccioni M, Dei S, Guandalini L, Martelli C, Manetti D, Martini E, Marucci G, Nesi M, Romanelli MN, Teodori E, Gualtieri F. Scapecchi S, et al. Among authors: guandalini l. J Med Chem. 2006 Mar 23;49(6):1925-31. doi: 10.1021/jm0510878. J Med Chem. 2006. PMID: 16539379
Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure.
Dei S, Bellucci C, Buccioni M, Ferraroni M, Guandalini L, Manetti D, Martini E, Marucci G, Matucci R, Nesi M, Romanelli MN, Scapecchi S, Teodori E. Dei S, et al. Among authors: guandalini l. J Med Chem. 2007 Mar 22;50(6):1409-13. doi: 10.1021/jm061374r. Epub 2007 Feb 17. J Med Chem. 2007. PMID: 17305327
Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives.
Dei S, Bellucci C, Buccioni M, Ferraroni M, Guandalini L, Manetti D, Marucci G, Matucci R, Nesi M, Romanelli MN, Scapecchi S, Teodori E. Dei S, et al. Among authors: guandalini l. Bioorg Med Chem. 2008 May 15;16(10):5490-500. doi: 10.1016/j.bmc.2008.04.013. Epub 2008 Apr 11. Bioorg Med Chem. 2008. PMID: 18455407
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists.
Scapecchi S, Nesi M, Matucci R, Bellucci C, Buccioni M, Dei S, Guandalini L, Manetti D, Martini E, Marucci G, Romanelli MN, Teodori E, Cirilli R. Scapecchi S, et al. Among authors: guandalini l. J Med Chem. 2008 Jul 10;51(13):3905-12. doi: 10.1021/jm800145d. Epub 2008 Jun 11. J Med Chem. 2008. PMID: 18543900
54 results