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Page 1
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.
Guandalini L, Martino MV, Di Cesare Mannelli L, Bartolucci G, Melani F, Malik R, Dei S, Floriddia E, Manetti D, Orlandi F, Teodori E, Ghelardini C, Romanelli MN. Guandalini L, et al. Among authors: melani f. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1700-1704. doi: 10.1016/j.bmcl.2015.03.009. Epub 2015 Mar 12. Bioorg Med Chem Lett. 2015. PMID: 25813160
Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: synthesis, biological evaluation and 3D-QSAR investigation.
Selleri S, Gratteri P, Costagli C, Bonaccini C, Costanzo A, Melani F, Guerrini G, Ciciani G, Costa B, Spinetti F, Martini C, Bruni F. Selleri S, et al. Among authors: melani f. Bioorg Med Chem. 2005 Aug 15;13(16):4821-34. doi: 10.1016/j.bmc.2005.05.015. Bioorg Med Chem. 2005. PMID: 15975799
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies.
Guerrini G, Ciciani G, Cambi G, Bruni F, Selleri S, Melani F, Montali M, Martini C, Ghelardini C, Norcini M, Costanzo A. Guerrini G, et al. Among authors: melani f. Bioorg Med Chem. 2008 Apr 15;16(8):4471-89. doi: 10.1016/j.bmc.2008.02.058. Epub 2008 Mar 5. Bioorg Med Chem. 2008. PMID: 18325771
Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse agonism.
Guerrini G, Ciciani G, Cambi G, Bruni F, Selleri S, Guarino C, Melani F, Montali M, Martini C, Ghelardini C, Norcini M, Costanzo A. Guerrini G, et al. Among authors: melani f. J Med Chem. 2009 Aug 13;52(15):4668-82. doi: 10.1021/jm801599a. J Med Chem. 2009. PMID: 19591485
New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on γ-aminobutyrric acid type A (GABA(A)) receptor. Design, synthesis, biological, and molecular modeling investigation.
Guerrini G, Ciciani G, Bruni F, Selleri S, Guarino C, Melani F, Montali M, Daniele S, Martini C, Ghelardini C, Norcini M, Ciattini S, Costanzo A. Guerrini G, et al. Among authors: melani f. J Med Chem. 2010 Nov 11;53(21):7532-48. doi: 10.1021/jm1001887. J Med Chem. 2010. PMID: 20939501
177 results