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Page 1
Not all Shc's roads lead to Ras.
Bonfini L, Migliaccio E, Pelicci G, Lanfrancone L, Pelicci PG. Bonfini L, et al. Among authors: pelicci pg, pelicci g. Trends Biochem Sci. 1996 Jul;21(7):257-61. Trends Biochem Sci. 1996. PMID: 8755247 Review.
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.
Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, Milia E, Padura IM, Raker VA, Maccarana M, Petronilli V, Minucci S, Bernardi P, Lanfrancone L, Pelicci PG. Trinei M, et al. Among authors: pelicci pg. Oncogene. 2002 May 30;21(24):3872-8. doi: 10.1038/sj.onc.1205513. Oncogene. 2002. PMID: 12032825
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.
Napoli C, Martin-Padura I, de Nigris F, Giorgio M, Mansueto G, Somma P, Condorelli M, Sica G, De Rosa G, Pelicci P. Napoli C, et al. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2112-6. doi: 10.1073/pnas.0336359100. Epub 2003 Feb 5. Proc Natl Acad Sci U S A. 2003. PMID: 12571362 Free PMC article.
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
Pacini S, Pellegrini M, Migliaccio E, Patrussi L, Ulivieri C, Ventura A, Carraro F, Naldini A, Lanfrancone L, Pelicci P, Baldari CT. Pacini S, et al. Mol Cell Biol. 2004 Feb;24(4):1747-57. doi: 10.1128/MCB.24.4.1747-1757.2004. Mol Cell Biol. 2004. PMID: 14749389 Free PMC article.
The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.
Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG. Orsini F, et al. Among authors: pelicci pg. J Biol Chem. 2004 Jun 11;279(24):25689-95. doi: 10.1074/jbc.M401844200. Epub 2004 Apr 12. J Biol Chem. 2004. PMID: 15078873 Free article.
p66ShcA modulates tissue response to hindlimb ischemia.
Zaccagnini G, Martelli F, Fasanaro P, Magenta A, Gaetano C, Di Carlo A, Biglioli P, Giorgio M, Martin-Padura I, Pelicci PG, Capogrossi MC. Zaccagnini G, et al. Among authors: pelicci pg. Circulation. 2004 Jun 15;109(23):2917-23. doi: 10.1161/01.CIR.0000129309.58874.0F. Epub 2004 Jun 1. Circulation. 2004. PMID: 15173034
547 results