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Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
Sandur SK, Ichikawa H, Sethi G, Ahn KS, Aggarwal BB. Sandur SK, et al. Among authors: ahn ks. J Biol Chem. 2006 Jun 23;281(25):17023-17033. doi: 10.1074/jbc.M601595200. Epub 2006 Apr 19. J Biol Chem. 2006. PMID: 16624823 Free article.
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