Harris M - Search Results

1

Heavy atom labeled nucleotides for measurement of kinetic isotope effects.

Weissman BP, Li NS, York D, Harris M, Piccirilli JA. Weissman BP, et al. Among authors: harris m. Biochim Biophys Acta. 2015 Nov;1854(11):1737-45. doi: 10.1016/j.bbapap.2015.03.007. Epub 2015 Mar 27. Biochim Biophys Acta. 2015. PMID: 25828952 Free PMC article. Review.

2

Understanding the transition states of phosphodiester bond cleavage: insights from heavy atom isotope effects.

Cassano AG, Anderson VE, Harris ME. Cassano AG, et al. Biopolymers. 2004 Jan;73(1):110-29. doi: 10.1002/bip.10517. Biopolymers. 2004. PMID: 14691944 Review.

3

Efficient synthesis of [2'-18O]uridine and its incorporation into oligonucleotides: a new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis.

Dai Q, Frederiksen JK, Anderson VE, Harris ME, Piccirilli JA. Dai Q, et al. J Org Chem. 2008 Jan 4;73(1):309-11. doi: 10.1021/jo701727h. Epub 2007 Dec 4. J Org Chem. 2008. PMID: 18052189

4

Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base.

Harris ME, Dai Q, Gu H, Kellerman DL, Piccirilli JA, Anderson VE. Harris ME, et al. J Am Chem Soc. 2010 Aug 25;132(33):11613-21. doi: 10.1021/ja103550e. J Am Chem Soc. 2010. PMID: 20669950 Free PMC article.

5

Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment.

Wong KY, Gu H, Zhang S, Piccirilli JA, Harris ME, York DM. Wong KY, et al. Among authors: harris me. Angew Chem Int Ed Engl. 2012 Jan 16;51(3):647-51. doi: 10.1002/anie.201104147. Epub 2011 Nov 11. Angew Chem Int Ed Engl. 2012. PMID: 22076983 Free PMC article. No abstract available.

6

Characterization of the Structure and Dynamics of the HDV Ribozyme at Different Stages Along the Reaction Path.

Lee TS, Giambaşu G, Harris ME, York DM. Lee TS, et al. Among authors: harris me. J Phys Chem Lett. 2011 Oct 20;2(20):2538-2543. doi: 10.1021/jz201106y. J Phys Chem Lett. 2011. PMID: 22200005 Free PMC article.

7

Molecular simulations of RNA 2'-O-transesterification reaction models in solution.

Radak BK, Harris ME, York DM. Radak BK, et al. Among authors: harris me. J Phys Chem B. 2013 Jan 10;117(1):94-103. doi: 10.1021/jp3084277. Epub 2012 Dec 24. J Phys Chem B. 2013. PMID: 23214417 Free PMC article.

8

Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation.

Gu H, Zhang S, Wong KY, Radak BK, Dissanayake T, Kellerman DL, Dai Q, Miyagi M, Anderson VE, York DM, Piccirilli JA, Harris ME. Gu H, et al. Among authors: harris me. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13002-7. doi: 10.1073/pnas.1215086110. Epub 2013 Jul 22. Proc Natl Acad Sci U S A. 2013. PMID: 23878223 Free PMC article.

9

Altered (transition) states: mechanisms of solution and enzyme catalyzed RNA 2'-O-transphosphorylation.

Kellerman DL, York DM, Piccirilli JA, Harris ME. Kellerman DL, et al. Among authors: harris me. Curr Opin Chem Biol. 2014 Aug;21:96-102. doi: 10.1016/j.cbpa.2014.06.010. Epub 2014 Jul 12. Curr Opin Chem Biol. 2014. PMID: 25023967 Free PMC article. Review.

10

Mechanistic insights into RNA transphosphorylation from kinetic isotope effects and linear free energy relationships of model reactions.

Chen H, Giese TJ, Huang M, Wong KY, Harris ME, York DM. Chen H, et al. Among authors: harris me. Chemistry. 2014 Oct 27;20(44):14336-43. doi: 10.1002/chem.201403862. Epub 2014 Sep 15. Chemistry. 2014. PMID: 25223953 Free PMC article.

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