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RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications.
Suárez-Fariñas M, Ungar B, Correa da Rosa J, Ewald DA, Rozenblit M, Gonzalez J, Xu H, Zheng X, Peng X, Estrada YD, Dillon SR, Krueger JG, Guttman-Yassky E. Suárez-Fariñas M, et al. Among authors: xu h. J Allergy Clin Immunol. 2015 May;135(5):1218-27. doi: 10.1016/j.jaci.2015.03.003. Epub 2015 Mar 31. J Allergy Clin Immunol. 2015. PMID: 25840722
Dust mite induces multiple polar T cell axes in human skin.
Malik K, Ungar B, Garcet S, Dutt R, Dickstein D, Zheng X, Xu H, Estrada YD, Suárez-Fariñas M, Shemer A, Krueger JG, Guttman-Yassky E. Malik K, et al. Among authors: xu h. Clin Exp Allergy. 2017 Dec;47(12):1648-1660. doi: 10.1111/cea.13040. Epub 2017 Nov 6. Clin Exp Allergy. 2017. PMID: 28977706
Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response.
Dhingra N, Shemer A, Correa da Rosa J, Rozenblit M, Fuentes-Duculan J, Gittler JK, Finney R, Czarnowicki T, Zheng X, Xu H, Estrada YD, Cardinale I, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Dhingra N, et al. Among authors: xu h. J Allergy Clin Immunol. 2014 Aug;134(2):362-72. doi: 10.1016/j.jaci.2014.03.009. Epub 2014 Apr 25. J Allergy Clin Immunol. 2014. PMID: 24768652
Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology.
Khattri S, Shemer A, Rozenblit M, Dhingra N, Czarnowicki T, Finney R, Gilleaudeau P, Sullivan-Whalen M, Zheng X, Xu H, Cardinale I, de Guzman Strong C, Gonzalez J, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Khattri S, et al. Among authors: xu h. J Allergy Clin Immunol. 2014 Jun;133(6):1626-34. doi: 10.1016/j.jaci.2014.03.003. Epub 2014 Apr 29. J Allergy Clin Immunol. 2014. PMID: 24786238 Free PMC article.
Residual genomic profile after cyclosporine treatment may offer insights into atopic dermatitis reoccurrence.
Rozenblit M, Suarez-Farinas M, Shemer A, Khattri S, Gilleaudeau P, Sullivan-Whalen M, Zheng X, Xu H, Cardinale I, Krueger JG, Guttman-Yassky E. Rozenblit M, et al. Among authors: xu h. J Allergy Clin Immunol. 2014 Oct;134(4):955-7. doi: 10.1016/j.jaci.2014.05.024. Epub 2014 Jul 2. J Allergy Clin Immunol. 2014. PMID: 24996261 Free PMC article. No abstract available.
Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin.
Correa da Rosa J, Malajian D, Shemer A, Rozenblit M, Dhingra N, Czarnowicki T, Khattri S, Ungar B, Finney R, Xu H, Zheng X, Estrada YD, Peng X, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Correa da Rosa J, et al. Among authors: xu h. J Allergy Clin Immunol. 2015 Mar;135(3):712-20. doi: 10.1016/j.jaci.2014.11.017. Epub 2015 Jan 10. J Allergy Clin Immunol. 2015. PMID: 25583101
Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population.
Czarnowicki T, Gonzalez J, Shemer A, Malajian D, Xu H, Zheng X, Khattri S, Gilleaudeau P, Sullivan-Whalen M, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Czarnowicki T, et al. Among authors: xu h. J Allergy Clin Immunol. 2015 Jul;136(1):104-115.e7. doi: 10.1016/j.jaci.2015.01.020. Epub 2015 Mar 3. J Allergy Clin Immunol. 2015. PMID: 25748064
Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets.
Czarnowicki T, Esaki H, Gonzalez J, Malajian D, Shemer A, Noda S, Talasila S, Berry A, Gray J, Becker L, Estrada Y, Xu H, Zheng X, Suárez-Fariñas M, Krueger JG, Paller AS, Guttman-Yassky E. Czarnowicki T, et al. Among authors: xu h. J Allergy Clin Immunol. 2015 Oct;136(4):941-951.e3. doi: 10.1016/j.jaci.2015.05.049. Epub 2015 Aug 1. J Allergy Clin Immunol. 2015. PMID: 26242300 Free PMC article.
Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing.
Suárez-Fariñas M, Ungar B, Noda S, Shroff A, Mansouri Y, Fuentes-Duculan J, Czernik A, Zheng X, Estrada YD, Xu H, Peng X, Shemer A, Krueger JG, Lebwohl MG, Guttman-Yassky E. Suárez-Fariñas M, et al. Among authors: xu h. J Allergy Clin Immunol. 2015 Nov;136(5):1277-87. doi: 10.1016/j.jaci.2015.06.032. Epub 2015 Aug 24. J Allergy Clin Immunol. 2015. PMID: 26316095
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