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SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation.
D'Antona L, Amato R, Talarico C, Ortuso F, Menniti M, Dattilo V, Iuliano R, Gigliotti F, Artese A, Costa G, Schenone S, Musumeci F, Abbruzzese C, Botta L, Trapasso F, Alcaro S, Paggi MG, Perrotti N. D'Antona L, et al. Among authors: dattilo v. Cell Physiol Biochem. 2015;35(5):2006-18. doi: 10.1159/000374008. Epub 2015 Mar 27. Cell Physiol Biochem. 2015. PMID: 25871776 Free article.
Protein tyrosine phosphatase PTPRJ is negatively regulated by microRNA-328.
Paduano F, Dattilo V, Narciso D, Bilotta A, Gaudio E, Menniti M, Agosti V, Palmieri C, Perrotti N, Fusco A, Trapasso F, Iuliano R. Paduano F, et al. Among authors: dattilo v. FEBS J. 2013 Jan;280(2):401-12. doi: 10.1111/j.1742-4658.2012.08624.x. Epub 2012 May 30. FEBS J. 2013. PMID: 22564856 Free article.
The role of microRNAs in cancer susceptibility.
Iuliano R, Vismara MF, Dattilo V, Trapasso F, Baudi F, Perrotti N. Iuliano R, et al. Among authors: dattilo v. Biomed Res Int. 2013;2013:591931. doi: 10.1155/2013/591931. Epub 2013 Mar 19. Biomed Res Int. 2013. PMID: 23586049 Free PMC article. Review.
Discovery of PTPRJ agonist peptides that effectively inhibit in vitro cancer cell proliferation and tube formation.
Ortuso F, Paduano F, Carotenuto A, Gomez-Monterrey I, Bilotta A, Gaudio E, Sala M, Artese A, Vernieri E, Dattilo V, Iuliano R, Brancaccio D, Bertamino A, Musella S, Alcaro S, Grieco P, Perrotti N, Croce CM, Novellino E, Fusco A, Campiglia P, Trapasso F. Ortuso F, et al. Among authors: dattilo v. ACS Chem Biol. 2013 Jul 19;8(7):1497-506. doi: 10.1021/cb3007192. Epub 2013 May 13. ACS Chem Biol. 2013. PMID: 23627474
Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release.
Russo E, Andreozzi F, Iuliano R, Dattilo V, Procopio T, Fiume G, Mimmi S, Perrotti N, Citraro R, Sesti G, Constanti A, De Sarro G. Russo E, et al. Among authors: dattilo v. Brain Behav Immun. 2014 Nov;42:157-68. doi: 10.1016/j.bbi.2014.06.016. Epub 2014 Jul 3. Brain Behav Immun. 2014. PMID: 24998197
Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.
Talarico C, D'Antona L, Scumaci D, Barone A, Gigliotti F, Fiumara CV, Dattilo V, Gallo E, Visca P, Ortuso F, Abbruzzese C, Botta L, Schenone S, Cuda G, Alcaro S, Bianco C, Lavia P, Paggi MG, Perrotti N, Amato R. Talarico C, et al. Among authors: dattilo v. Oncotarget. 2015 Nov 10;6(35):37511-25. doi: 10.18632/oncotarget.5527. Oncotarget. 2015. PMID: 26462020 Free PMC article.
SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells.
Talarico C, Dattilo V, D'Antona L, Barone A, Amodio N, Belviso S, Musumeci F, Abbruzzese C, Bianco C, Trapasso F, Schenone S, Alcaro S, Ortuso F, Florio T, Paggi MG, Perrotti N, Amato R. Talarico C, et al. Among authors: dattilo v. Oncotarget. 2016 Mar 29;7(13):15868-84. doi: 10.18632/oncotarget.7520. Oncotarget. 2016. PMID: 26908461 Free PMC article.
76 results