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Therapeutic immunization with a mixture of herpes simplex virus 1 glycoprotein D-derived “asymptomatic” human CD8+ T-cell epitopes decreases spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low frequency of local PD-1+ TIM-3+ CD8+ exhausted T cells.
Khan AA, Srivastava R, Chentoufi AA, Geertsema R, Thai NT, Dasgupta G, Osorio N, Kalantari M, Nesburn AB, Wechsler SL, BenMohamed L. Khan AA, et al. Among authors: dasgupta g. J Virol. 2015 Jul;89(13):6619-32. doi: 10.1128/JVI.00788-15. J Virol. 2015. PMID: 25878105 Free PMC article.
Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection.
Nesburn AB, Bettahi I, Dasgupta G, Chentoufi AA, Zhang X, You S, Morishige N, Wahlert AJ, Brown DJ, Jester JV, Wechsler SL, BenMohamed L. Nesburn AB, et al. Among authors: dasgupta g. J Virol. 2007 Jul;81(14):7647-61. doi: 10.1128/JVI.00294-07. Epub 2007 May 2. J Virol. 2007. PMID: 17475646 Free PMC article.
The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism.
Chentoufi AA, Kritzer E, Tran MV, Dasgupta G, Lim CH, Yu DC, Afifi RE, Jiang X, Carpenter D, Osorio N, Hsiang C, Nesburn AB, Wechsler SL, BenMohamed L. Chentoufi AA, et al. Among authors: dasgupta g. J Virol. 2011 Sep;85(17):9127-38. doi: 10.1128/JVI.00587-11. Epub 2011 Jun 29. J Virol. 2011. PMID: 21715478 Free PMC article.
Immunodominant "asymptomatic" herpes simplex virus 1 and 2 protein antigens identified by probing whole-ORFome microarrays with serum antibodies from seropositive asymptomatic versus symptomatic individuals.
Dasgupta G, Chentoufi AA, Kalantari M, Falatoonzadeh P, Chun S, Lim CH, Felgner PL, Davies DH, BenMohamed L. Dasgupta G, et al. J Virol. 2012 Apr;86(8):4358-69. doi: 10.1128/JVI.07107-11. Epub 2012 Feb 8. J Virol. 2012. PMID: 22318137 Free PMC article.
59 results