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Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5.
Picon S, Boulahjar R, Hoguet V, Baron M, Duplan I, Vallez E, Hennuyer N, Dumont J, Touche V, Dorchies E, Lasalle M, Descat A, Piveteau C, Biela A, Chaput L, Villoutreix BO, Lipka E, Sevin E, Culot M, Gosselet F, Lestavel S, Roussel P, Deprez-Poulain R, Leroux F, Staels B, Deprez B, Tailleux A, Charton J. Picon S, et al. J Med Chem. 2023 Sep 14;66(17):11732-11760. doi: 10.1021/acs.jmedchem.2c01881. Epub 2023 Aug 28. J Med Chem. 2023. PMID: 37639383
Alkene syn dihydroxylation with malonoyl peroxides.
Griffith JC, Jones KM, Picon S, Rawling MJ, Kariuki BM, Campbell M, Tomkinson NC. Griffith JC, et al. Among authors: picon s. J Am Chem Soc. 2010 Oct 20;132(41):14409-11. doi: 10.1021/ja1066674. J Am Chem Soc. 2010. PMID: 20866057
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